Angiomodulatory and neurological effects of ginsenosides

K. W. Leung, Kin Lam YUNG, Nai Ki MAK, Patrick Y K YUE, H. B. Luo, Yuen Kit CHENG*, T. P.D. Fan, H. W. Yueng, T. B. Ng, Ricky N S WONG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)

Abstract

Panax ginseng C.A. Meyer, one of the most popular and valued herbs, has been used extensively in traditional Chinese medicine for thousands of years. More than thirty ginsenosides, the pharmacologically active ingredients in ginseng, have been identified with various sugar moieties attached at the C-3, C-6 and C-20 positions of the steroidal skeleton. We herein review the current literature on the pharmacological effects of ginsenosides on the modulation of angiogenesis, dysregulations of which contribute towards many pathological conditions. Regarding the adaptogenic property of ginseng, the effects of ginsenosides on central nervous system are also discussed. Recent researches have pointed to the steroid hormone receptors as the target molecules to elicit the diverse cellular and physiological activities of ginseng. We believe that understanding the interaction between ginsenosides and various steroid hormone receptors may provide clues to unravel the secret of ginseng.

Original languageEnglish
Pages (from-to)1371-1380
Number of pages10
JournalCurrent Medicinal Chemistry
Volume14
Issue number12
DOIs
Publication statusPublished - May 2007

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Angiogenesis
  • Angiotherapy
  • Cognitive functions
  • Ginseng
  • Ginsenosides
  • Neuroprotection
  • Steroid hormone receptors

Fingerprint

Dive into the research topics of 'Angiomodulatory and neurological effects of ginsenosides'. Together they form a unique fingerprint.

Cite this