Angiogenesis: from plants to blood vessels

Tai Ping Fan; Ju Ching Yeh; Kar Wah Leung; Patrick Y K YUE; Ricky N S WONG

doi:10.1016/j.tips.2006.04.006

Angiogenesis: from plants to blood vessels

Tai Ping Fan^*, Ju Ching Yeh, Kar Wah Leung, Patrick Y K YUE, Ricky N S WONG

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

221 Citations (Scopus)

Abstract

Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more effective approaches are required. The identification of new drugs from plants has a long and successful history, and certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine (TCM) for thousands of years. Similar to Western combination therapy, TCM uses mixtures of plant extracts, termed fufang, to maximize efficacy and minimize adverse effects or toxicity. More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.

Original language	English
Pages (from-to)	297-309
Number of pages	13
Journal	Trends in Pharmacological Sciences
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.tips.2006.04.006
Publication status	Published - Jun 2006

Scopus Subject Areas

Toxicology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tips.2006.04.006

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@article{da9e48113044498b942bf1653d0563e8,

title = "Angiogenesis: from plants to blood vessels",

abstract = "Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more effective approaches are required. The identification of new drugs from plants has a long and successful history, and certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine (TCM) for thousands of years. Similar to Western combination therapy, TCM uses mixtures of plant extracts, termed fufang, to maximize efficacy and minimize adverse effects or toxicity. More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.",

author = "Fan, {Tai Ping} and Yeh, {Ju Ching} and Leung, {Kar Wah} and YUE, {Patrick Y K} and WONG, {Ricky N S}",

note = "Funding Information: The work in our laboratories was supported by grants from the Hong Kong Research Grants Committee, Hong Kong Baptist University and NuLiv Science Taiwan. J-C.Y. is in receipt of a Cambridge Overseas Trust scholarship. We thank Mick Bakhle, Brian Callingham, Dan Jiang, Pieter Koolwijk, Steve Ley, Bo-Ying Ma and Rebecca Myers for their critical review of and invaluable suggestions regarding the manuscript. T-P.F. dedicates this article to his mentors, the late Graham Lewis and John Vane.",

year = "2006",

month = jun,

doi = "10.1016/j.tips.2006.04.006",

language = "English",

volume = "27",

pages = "297--309",

journal = "Trends in Pharmacological Sciences",

issn = "0165-6147",

publisher = "Elsevier Ltd.",

number = "6",

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TY - JOUR

T1 - Angiogenesis

T2 - from plants to blood vessels

AU - Fan, Tai Ping

AU - Yeh, Ju Ching

AU - Leung, Kar Wah

AU - YUE, Patrick Y K

AU - WONG, Ricky N S

N1 - Funding Information: The work in our laboratories was supported by grants from the Hong Kong Research Grants Committee, Hong Kong Baptist University and NuLiv Science Taiwan. J-C.Y. is in receipt of a Cambridge Overseas Trust scholarship. We thank Mick Bakhle, Brian Callingham, Dan Jiang, Pieter Koolwijk, Steve Ley, Bo-Ying Ma and Rebecca Myers for their critical review of and invaluable suggestions regarding the manuscript. T-P.F. dedicates this article to his mentors, the late Graham Lewis and John Vane.

PY - 2006/6

Y1 - 2006/6

N2 - Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more effective approaches are required. The identification of new drugs from plants has a long and successful history, and certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine (TCM) for thousands of years. Similar to Western combination therapy, TCM uses mixtures of plant extracts, termed fufang, to maximize efficacy and minimize adverse effects or toxicity. More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.

AB - Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more effective approaches are required. The identification of new drugs from plants has a long and successful history, and certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine (TCM) for thousands of years. Similar to Western combination therapy, TCM uses mixtures of plant extracts, termed fufang, to maximize efficacy and minimize adverse effects or toxicity. More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.

UR - http://www.scopus.com/inward/record.url?scp=33744902836&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2006.04.006

DO - 10.1016/j.tips.2006.04.006

M3 - Review article

C2 - 16697473

AN - SCOPUS:33744902836

SN - 0165-6147

VL - 27

SP - 297

EP - 309

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 6

ER -

Angiogenesis: from plants to blood vessels

Abstract

Scopus Subject Areas

UN SDGs

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