Angiogenesis: from plants to blood vessels

Tai Ping Fan*, Ju Ching Yeh, Kar Wah Leung, Patrick Y K YUE, Ricky N S WONG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

193 Citations (Scopus)

Abstract

Angiogenesis is a major pathological component of diseases such as cancer and coronary heart disease. Although major advances have been made and encouraging clinical results obtained, safer and more effective approaches are required. The identification of new drugs from plants has a long and successful history, and certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine (TCM) for thousands of years. Similar to Western combination therapy, TCM uses mixtures of plant extracts, termed fufang, to maximize efficacy and minimize adverse effects or toxicity. More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.

Original languageEnglish
Pages (from-to)297-309
Number of pages13
JournalTrends in Pharmacological Sciences
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 2006

Scopus Subject Areas

  • Toxicology
  • Pharmacology

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