Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies

Keyphrases

• Cyclin-dependent Kinase 4 (CDK4) 100%
• Protein Function 100%
• Potential Inhibitors 100%
• Molecular Dynamics Study 100%
• Mutation Effect 100%
• Molecular Modeling Studies 100%
• Cyclin D1 (CCND1) 36%
• NsSNPs 36%
• Binding Affinity 27%
• Genetic Variation 18%
• Flavopiridol 18%
• Prediction Method 9%
• Computational Investigation 9%
• P-hydroxyphenyl 9%
• Virtual Screening 9%
• Protein Complex 9%
• G1 Phase 9%
• Therapeutic Target 9%
• Sigma Phase 9%
• Molecular Docking 9%
• Docking Dynamics 9%
• Computational Prediction 9%
• Human Cancer 9%
• Personalized Treatment 9%
• Screening Approach 9%
• Integrated Computational Approach 9%
• Molecular Targeted Therapy 9%
• Protein-ligand 9%
• Somatic Genetics 9%
• Biological Phenomena 9%
• Diosmin 9%
• 4H-chromene 9%
• Cyclin Proteins 9%
• Rutin 9%

Biochemistry, Genetics and Molecular Biology

• Dynamics 100%
• Molecular Model 100%
• Protein Function 100%
• Cyclin-Dependent Kinase 4 100%
• Cyclin D1 36%
• Binding Affinity 27%
• Genetic Variation 18%
• Cell Cycle 9%
• Genetic Divergence 9%
• Protein Complexes 9%
• G1 Phase 9%
• Conformation 9%
• Cyclin-Dependent Kinase 9%
• S Phase 9%
• Trichloroethylene 9%
• Docking (Molecular) 9%
• Protein Ligand 9%
• Rutin 9%
• Diosmin 9%
• Cellular, Subcellular and Molecular Biological Phenomena and Functions 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Cyclin Dependent Kinase 4 100%
• Cyclin D1 36%
• Malignant Neoplasm 27%
• Flavopiridol 18%
• Virtual Screening 9%
• Protein Ligand 9%
• Diosmin 9%
• Trichloroethylene 9%
• Rutin 9%