Analysing the effect of mutation on protein function and discovering potential inhibitors of CDK4: Molecular modelling and dynamics studies

Medicine & Life Sciences

• Cyclin-Dependent Kinase 4 100%
• Molecular Dynamics Simulation 78%
• Mutation 39%
• Cyclin D1 33%
• Proteins 26%
• alvocidib 24%
• Carrier Proteins 20%
• Genetic Variation 15%
• Cyclin-Dependent Kinase Inhibitor Proteins 13%
• Diosmin 13%
• Genetic Phenomena 10%
• Rutin 10%
• Protein Conformation 10%
• Preclinical Drug Evaluations 9%
• G1 Phase 8%
• S Phase 7%
• Neoplasms 7%
• Biological Phenomena 7%
• Pharmaceutical Preparations 6%
• Genes 6%
• Cell Cycle 6%
• Ligands 5%

Agriculture & Biology

• cyclin-dependent kinase 91%
• mutation 48%
• cyclins 34%
• proteins 23%
• neoplasms 16%
• drugs 14%
• interphase 13%
• therapeutics 10%
• protein conformation 9%
• D1 protein 9%
• molecular dynamics 8%
• genetic variation 8%
• rutin 7%
• protein kinases 6%
• ligands 6%
• cell cycle 6%

Chemical Compounds

• Molecular Modeling 63%
• Mutation 59%
• Molecular Dynamics 51%
• Kd 32%
• Protein 29%
• Diosmin 24%
• Drug 22%
• Rutin 16%