Abstract
The ethanol extract of Chinese medicinal ants Polyrhachis lamelliden
was evaluated for its analgesic and anti-inflammatory activities in
mice. It was shown that the extract significantly inhibited acetic
acid-induced writhing response and increased hot-plate pain threshold of
mice at doses of 1.5 and 3.0 g crude drug/kg. Meanwhile, the extract
significantly inhibited the increase in vascular permeability induced by
acetic acid and in ear edema induced by xylene in mice. However, it had
no obvious effect on leukocyte migration induced by
carboxymethylcellulose sodium (CMC-Na). The ethanol extract suspended in
water was partitioned with diethyl ether, ethyl acetate and n-butanol
successively to yield four fractions including water fraction. Among
these fractions, diethyl ether and ethyl acetate fractions were found to
increase hot-plate pain threshold and to inhibit acetic acid-induced
writhing response in mice. Water fractions markedly inhibited acetic
acid-induced writhing response and reduced the dye leakage to the
peritoneal cavity induced by acetic acid and ear edema induced by
xylene. These results suggest that P. lamellidens presents
remarkable analgesic and anti-inflammatory activity, which supported the
traditional use of the medicinal ants in the treatment of various
diseases associated with inflammation. The diethyl ether fraction has
greater contribution to the overall analgesic activity, whereas the
water fraction showed the greatest anti-inflammatory and peripheral
analgesic activities.
| Original language | English |
|---|---|
| Pages (from-to) | 176-180 |
| Number of pages | 5 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2005 |
Scopus Subject Areas
- Pharmacology
- Pharmaceutical Science
User-Defined Keywords
- Polyrhachis lamellidens
- medicinal ant
- anti-inflammation
- analgesic
- pain threshold
- ear edema