An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification

Zhenyu Lin*, Weiqiang Yang, Guiyun Zhang, Qida Liu, Bin Qiu, Zongwei CAI, Guonan Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

A novel catalytic colorimetric assay assisted by nicking endonuclease signal amplification (NESA) was developed. With the signal amplification, the detection limit of the p53 target gene can be as low as 1 pM, which is nearly 5 orders of magnitude lower than that of other previously reported colorimetric DNA detection strategies based on catalytic DNAzyme.

Original languageEnglish
Pages (from-to)9069-9071
Number of pages3
JournalChemical Communications
Volume47
Issue number32
DOIs
Publication statusPublished - 28 Aug 2011

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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