An Ir(III) complex chemosensor for the detection of thiols

Zhifeng Mao; Jinbiao Liu; Tian Shu Kang; Wanhe Wang; Quan Bin Han; Chun Ming Wang; Chung Hang Leung; Dik Lung Ma

doi:10.1080/14686996.2016.1162081

An Ir(III) complex chemosensor for the detection of thiols

Zhifeng Mao
, Jinbiao Liu
, Tian Shu Kang
, Wanhe Wang
, Quan Bin Han
, Chun Ming Wang
, Chung Hang Leung
, Dik Lung Ma^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

27 Citations (Scopus)

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Abstract

In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.

Original language	English
Pages (from-to)	109-114
Number of pages	6
Journal	Science and Technology of Advanced Materials
Volume	17
Issue number	1
DOIs	https://doi.org/10.1080/14686996.2016.1162081
Publication status	Published - 2016

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Chemosensor
Iridium(III) complex
Thiols

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title = "An Ir(III) complex chemosensor for the detection of thiols",

abstract = "In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N\textasciicircum{}N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.",

keywords = "Chemosensor, Iridium(III) complex, Thiols",

author = "Zhifeng Mao and Jinbiao Liu and Kang, \{Tian Shu\} and Wanhe Wang and Han, \{Quan Bin\} and Wang, \{Chun Ming\} and Leung, \{Chung Hang\} and Ma, \{Dik Lung\}",

note = "Funding Information: This work is supported by Hong Kong Baptist University FRG2/14-15/004 and FRG2/15-16/002), the Health and Medical Research Fund [HMRF/14130522], the Research, Grants Council [HKBU/201811, HKBU/204612 and HKBU/201913], the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (A-HKBU201/12; Oligoswitch ANR-12-IS07-0001), National Natural Science Foundation of China [21575121], Guangdong Province Natural Science Foundation [2015A030313816], Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme [RC-IRMS/14-15/06], the Science and Technology Development Fund, Macao SAR [098/2014/A2], the University of Macau [MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMSQRCM, MRG023/LCH/2013/ ICMS and MRG044/LCH/2015/ICMS)].",

year = "2016",

doi = "10.1080/14686996.2016.1162081",

language = "English",

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pages = "109--114",

journal = "Science and Technology of Advanced Materials",

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AU - Mao, Zhifeng

AU - Liu, Jinbiao

AU - Kang, Tian Shu

AU - Wang, Wanhe

AU - Han, Quan Bin

AU - Wang, Chun Ming

AU - Leung, Chung Hang

AU - Ma, Dik Lung

N1 - Funding Information: This work is supported by Hong Kong Baptist University FRG2/14-15/004 and FRG2/15-16/002), the Health and Medical Research Fund [HMRF/14130522], the Research, Grants Council [HKBU/201811, HKBU/204612 and HKBU/201913], the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (A-HKBU201/12; Oligoswitch ANR-12-IS07-0001), National Natural Science Foundation of China [21575121], Guangdong Province Natural Science Foundation [2015A030313816], Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme [RC-IRMS/14-15/06], the Science and Technology Development Fund, Macao SAR [098/2014/A2], the University of Macau [MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMSQRCM, MRG023/LCH/2013/ ICMS and MRG044/LCH/2015/ICMS)].

PY - 2016

Y1 - 2016

N2 - In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.

AB - In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.

KW - Chemosensor

KW - Iridium(III) complex

KW - Thiols

UR - https://www.scopus.com/pages/publications/84969930844

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DO - 10.1080/14686996.2016.1162081

M3 - Journal article

AN - SCOPUS:84969930844

SN - 1468-6996

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SP - 109

EP - 114

JO - Science and Technology of Advanced Materials

JF - Science and Technology of Advanced Materials

IS - 1

ER -

An Ir(III) complex chemosensor for the detection of thiols

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