An insight into anti-inflammatory effects of fungal beta-glucans

Bin Du; Chengyuan Lin; Zhaoxiang BIAN; Baojun Xu

doi:10.1016/j.tifs.2014.09.002

An insight into anti-inflammatory effects of fungal beta-glucans

Bin Du
, Chengyuan Lin
, Zhaoxiang BIAN^*
, Baojun Xu

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

192 Citations (Scopus)

Abstract

β-Glucans from fungi exhibit a broad spectrum of biological activities including anti-tumor, immune-modulating and anti-inflammatory properties. The anti-inflammatory effect is mediated through the regulation of various inflammatory cytokines, such as nitric oxide (NO), interleukins (ILs), tumor necrosis factor alpha (TNF)-α, interferon gamma (INF)-γ as well as non-cytokine mediator, prostaglandin E₂ (PGE₂). Up to now, the anti-inflammatory activity of β-glucans has received little attention. It is worthwhile to investigate the anti-inflammatory properties of fungal β-glucans in a separate review, discussing invitro studies, animal studies and human studies on anti-inflammation effects of fungal β-glucans, as well as the structure-anti-inflammatory activity relationships.

Original language	English
Pages (from-to)	49-59
Number of pages	11
Journal	Trends in Food Science and Technology
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.tifs.2014.09.002
Publication status	Published - 1 Jan 2015

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10.1016/j.tifs.2014.09.002

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title = "An insight into anti-inflammatory effects of fungal beta-glucans",

abstract = "β-Glucans from fungi exhibit a broad spectrum of biological activities including anti-tumor, immune-modulating and anti-inflammatory properties. The anti-inflammatory effect is mediated through the regulation of various inflammatory cytokines, such as nitric oxide (NO), interleukins (ILs), tumor necrosis factor alpha (TNF)-α, interferon gamma (INF)-γ as well as non-cytokine mediator, prostaglandin E2 (PGE2). Up to now, the anti-inflammatory activity of β-glucans has received little attention. It is worthwhile to investigate the anti-inflammatory properties of fungal β-glucans in a separate review, discussing invitro studies, animal studies and human studies on anti-inflammation effects of fungal β-glucans, as well as the structure-anti-inflammatory activity relationships.",

author = "Bin Du and Chengyuan Lin and Zhaoxiang BIAN and Baojun Xu",

note = "Funding Information: This project is jointly supported by Natural Science Foundation of Guangdong Province, China (Project Code: S2012010008961), and by Beijing Normal University-Hong Kong Baptist University United International College (grant number: UIC201329 ). ",

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doi = "10.1016/j.tifs.2014.09.002",

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T1 - An insight into anti-inflammatory effects of fungal beta-glucans

AU - Du, Bin

AU - Lin, Chengyuan

AU - BIAN, Zhaoxiang

AU - Xu, Baojun

N1 - Funding Information: This project is jointly supported by Natural Science Foundation of Guangdong Province, China (Project Code: S2012010008961), and by Beijing Normal University-Hong Kong Baptist University United International College (grant number: UIC201329 ).

PY - 2015/1/1

Y1 - 2015/1/1

N2 - β-Glucans from fungi exhibit a broad spectrum of biological activities including anti-tumor, immune-modulating and anti-inflammatory properties. The anti-inflammatory effect is mediated through the regulation of various inflammatory cytokines, such as nitric oxide (NO), interleukins (ILs), tumor necrosis factor alpha (TNF)-α, interferon gamma (INF)-γ as well as non-cytokine mediator, prostaglandin E2 (PGE2). Up to now, the anti-inflammatory activity of β-glucans has received little attention. It is worthwhile to investigate the anti-inflammatory properties of fungal β-glucans in a separate review, discussing invitro studies, animal studies and human studies on anti-inflammation effects of fungal β-glucans, as well as the structure-anti-inflammatory activity relationships.

AB - β-Glucans from fungi exhibit a broad spectrum of biological activities including anti-tumor, immune-modulating and anti-inflammatory properties. The anti-inflammatory effect is mediated through the regulation of various inflammatory cytokines, such as nitric oxide (NO), interleukins (ILs), tumor necrosis factor alpha (TNF)-α, interferon gamma (INF)-γ as well as non-cytokine mediator, prostaglandin E2 (PGE2). Up to now, the anti-inflammatory activity of β-glucans has received little attention. It is worthwhile to investigate the anti-inflammatory properties of fungal β-glucans in a separate review, discussing invitro studies, animal studies and human studies on anti-inflammation effects of fungal β-glucans, as well as the structure-anti-inflammatory activity relationships.

UR - https://www.scopus.com/pages/publications/84919384281

U2 - 10.1016/j.tifs.2014.09.002

DO - 10.1016/j.tifs.2014.09.002

M3 - Review article

AN - SCOPUS:84919384281

SN - 0924-2244

VL - 41

SP - 49

EP - 59

JO - Trends in Food Science and Technology

JF - Trends in Food Science and Technology

IS - 1

ER -

An insight into anti-inflammatory effects of fungal beta-glucans

Abstract

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