An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

Yuanyuan Tian; Lei Zhang; Jingjing Shen; Lingzhi Wu; Hongzhang He; Dik Lung Ma; Chung Hang Leung; Weibing Wu; Quli Fan; Wei Huang; Lianhui Wang

doi:10.1002/smll.201600041

An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

Yuanyuan Tian
, Lei Zhang
, Jingjing Shen
, Lingzhi Wu
, Hongzhang He
, Dik Lung Ma
, Chung Hang Leung
, Weibing Wu
, Quli Fan^*
, Wei Huang
, Lianhui Wang

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

35 Citations (Scopus)

Abstract

Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K⁺). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.

Original language	English
Pages (from-to)	2913-2920
Number of pages	8
Journal	Small
Volume	12
Issue number	21
DOIs	https://doi.org/10.1002/smll.201600041
Publication status	Published - 1 Jun 2016

User-Defined Keywords

core-shell nanocubes
G-quadruplex
localized surface plasmon resonance
nanoaptasensors, biosensors

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10.1002/smll.201600041

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@article{c2224d4d4b1c4754bd135ef94d411ba7,

title = "An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex",

abstract = "Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.",

keywords = "core-shell nanocubes, G-quadruplex, localized surface plasmon resonance, nanoaptasensors, biosensors",

author = "Yuanyuan Tian and Lei Zhang and Jingjing Shen and Lingzhi Wu and Hongzhang He and Ma, \{Dik Lung\} and Leung, \{Chung Hang\} and Weibing Wu and Quli Fan and Wei Huang and Lianhui Wang",

note = "Funding Information: Y.Y.T. and L.Z. contributed equally to this work. For the financial support for this work, the authors thank the National Basic Research Program of China (Grant No. 2012CB933301), the National Natural Science Foundation of China (Grant Nos. 61205195, 61571239, 21475064, 61378081, and 31200453), the Program for Changjiang Scholars and Innovative Research Team in University (IRT-15R37), the Specialized Research Fund for Doctoral College (Grant Nos. 20123223120011 and 20123223110007), the Synergetic Innovation Center for Organic Electronics and Information Displays, the Priority Academic Program Development of Jiangsu Higher Education Institutions, and the Natural Science Foundation of Jiangsu Province, China (BM2012010, NY211003).",

year = "2016",

month = jun,

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doi = "10.1002/smll.201600041",

language = "English",

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journal = "Small",

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TY - JOUR

T1 - An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

AU - Tian, Yuanyuan

AU - Zhang, Lei

AU - Shen, Jingjing

AU - Wu, Lingzhi

AU - He, Hongzhang

AU - Ma, Dik Lung

AU - Leung, Chung Hang

AU - Wu, Weibing

AU - Fan, Quli

AU - Huang, Wei

AU - Wang, Lianhui

N1 - Funding Information: Y.Y.T. and L.Z. contributed equally to this work. For the financial support for this work, the authors thank the National Basic Research Program of China (Grant No. 2012CB933301), the National Natural Science Foundation of China (Grant Nos. 61205195, 61571239, 21475064, 61378081, and 31200453), the Program for Changjiang Scholars and Innovative Research Team in University (IRT-15R37), the Specialized Research Fund for Doctoral College (Grant Nos. 20123223120011 and 20123223110007), the Synergetic Innovation Center for Organic Electronics and Information Displays, the Priority Academic Program Development of Jiangsu Higher Education Institutions, and the Natural Science Foundation of Jiangsu Province, China (BM2012010, NY211003).

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.

AB - Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.

KW - core-shell nanocubes

KW - G-quadruplex

KW - localized surface plasmon resonance

KW - nanoaptasensors, biosensors

UR - https://www.scopus.com/pages/publications/84971507720

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DO - 10.1002/smll.201600041

M3 - Journal article

C2 - 27106517

AN - SCOPUS:84971507720

SN - 1613-6810

VL - 12

SP - 2913

EP - 2920

JO - Small

JF - Small

IS - 21

ER -

An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

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