An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

Yuanyuan Tian, Lei Zhang, Jingjing Shen, Lingzhi Wu, Hongzhang He, Edmond Dik Lung MA, Chung Hang Leung, Weibing Wu, Quli Fan*, Wei Huang, Lianhui Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.

Original languageEnglish
Pages (from-to)2913-2920
Number of pages8
JournalSmall
Volume12
Issue number21
DOIs
Publication statusPublished - 1 Jun 2016

Scopus Subject Areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

User-Defined Keywords

  • core-shell nanocubes
  • G-quadruplex
  • localized surface plasmon resonance
  • nanoaptasensors, biosensors

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