An example of a sequential uniform design: Application in capillary electrophoresis

Albert W M LEE, Wing Fat Chan*, Fion S.Y. Yuen, Ken P.K. Tse, Yizeng Liang, Kai Tai Fang

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

38 Citations (Scopus)


A new sequential uniform design procedure is developed in this paper. The uniform design based number-theoretic method recently developed in statistics was used for optimisation of electropherotic separation. The sequential procedure is introduced in order to reach the global optimisation for complete separation. The procedure was illustrated by separating five dithiocarbamate (DTC) compounds by capillary electrophoresis. These five DTC compounds, which failed to be separated by CE using the technique with changing one variable one time, were completely separated by the proposed procedure.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalChemometrics and Intelligent Laboratory Systems
Issue number1
Publication statusPublished - Nov 1997

Scopus Subject Areas

  • Analytical Chemistry
  • Software
  • Process Chemistry and Technology
  • Spectroscopy
  • Computer Science Applications

User-Defined Keywords

  • Capillary electrophoresis
  • Electropherotic separation
  • Global optimisation
  • Number-theoretic method
  • Uniform design


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