@article{967ea32c6d8145e3b0bd0a406bfc6c7e,
title = "An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication",
abstract = "Amin et al. provide in vivo evidence for an essential, cell-cycle-dependent, and likely semi-conservative ORC dimerization cycle that regulates eukaryotic chromosomal DNA replication. ORC dimers provide symmetric platforms to load the symmetric pre-RCs at replication origins. ORC de-dimerization produces two single hexamers to bind and protect the two nascent origins.",
keywords = "cell-cycle control, DNA replication, ORC dimerization, pre-RC formation, replication licensing",
author = "Aftab Amin and Rentian Wu and Cheung, \{Man Hei\} and Scott, \{John F.\} and Ziyi Wang and Zijing Zhou and Changdong Liu and Guang Zhu and Wong, \{Chris Kong Chu\} and Zhiling Yu and Chun Liang",
note = "Funding Information: We thank Bruce Stillman and Ulrich Laemmli for the kind gifts of yeast strains, plasmids, and/or antibodies and Yuanliang Zhai, Chuchu Zhang, Jiafeng Wang, Langhuan Pei, and Kelvin K.L. Sou for technical assistance. This work was supported by the Hong Kong Research Grants Council (GRF661713 and RGC No. 16103717), the Science and Technology Innovation Bureau of Guangzhou Development District (CY2019-005), and Hong Kong Baptist University, Research Committee, Initiation Grant - Faculty Niche Research Areas (IG-FNRA) 2018/19 (RC-FNRA-IG-18-19-SCM-01). Publisher copyright: {\textcopyright} 2020 The Author(s).",
year = "2020",
month = mar,
day = "10",
doi = "10.1016/j.celrep.2020.02.046",
language = "English",
volume = "30",
pages = "3323--3338.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "10",
}