@article{967ea32c6d8145e3b0bd0a406bfc6c7e,
title = "An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication",
abstract = "Amin et al. provide in vivo evidence for an essential, cell-cycle-dependent, and likely semi-conservative ORC dimerization cycle that regulates eukaryotic chromosomal DNA replication. ORC dimers provide symmetric platforms to load the symmetric pre-RCs at replication origins. ORC de-dimerization produces two single hexamers to bind and protect the two nascent origins.",
keywords = "cell-cycle control, DNA replication, ORC dimerization, pre-RC formation, replication licensing",
author = "Aftab Amin and Rentian Wu and Cheung, {Man Hei} and Scott, {John F.} and Ziyi Wang and Zijing Zhou and Changdong Liu and Guang Zhu and Wong, {Chris K C} and Zhiling Yu and Chun Liang",
note = "Funding Information: We thank Bruce Stillman and Ulrich Laemmli for the kind gifts of yeast strains, plasmids, and/or antibodies and Yuanliang Zhai, Chuchu Zhang, Jiafeng Wang, Langhuan Pei, and Kelvin K.L. Sou for technical assistance. This work was supported by the Hong Kong Research Grants Council ( GRF661713 and RGC No. 16103717 ), the Science and Technology Innovation Bureau of Guangzhou Development District ( CY2019-005 ), and Hong Kong Baptist University , Research Committee, Initiation Grant - Faculty Niche Research Areas (IG-FNRA) 2018/19 ( RC-FNRA-IG-18-19-SCM-01 ). ",
year = "2020",
month = mar,
day = "10",
doi = "10.1016/j.celrep.2020.02.046",
language = "English",
volume = "30",
pages = "3323--3338.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "10",
}