An Enhanced Massively Multi-agent System for Discovering HIV Population Dynamics

Shiwu Zhang*, Jie Yang, Yuehua Wu, Jiming Liu

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference proceedingpeer-review

3 Citations (Scopus)


In this paper, we present an enhanced massively multi-agent system based on the previous MMAS for discovering the unique dynamics of HIV infection [1]. The enhanced MMAS keeps the spacial characteristics of cellular automata (CA), and employs mathematical equations within sites. Furthermore, new features are incorporated into the model, such as the sequence representation of HIV genome, immune memory and agent remote diffusion among sites. The enhanced model is closer to the reality and the simulation captures two extreme time scales in the typical three stages dynamics of HIV infection, which make the model more convincing. The simulation also reveals two phase-transitions in the dynamics of the size of immune memory, and indicates that the high mutation rate of HIV is the fatal factor with which HIV destroys the immune system eventually. The enhanced MMAS provides a good tool to study HIV drug therapy for its characterizing the process of HIV infection.

Original languageEnglish
Title of host publicationAdvances in Intelligent Computing
Subtitle of host publicationInternational Conference on Intelligent Computing, ICIC 2005, Hefei, China, August 23-26, 2005, Proceedings, Part II
EditorsDe-Shuang Huang, Xiao-Ping Zhang, Guang-Bin Huang
Place of PublicationBerlin, Heidelberg
Number of pages10
ISBN (Electronic)9783540319078
ISBN (Print)9783540282273
Publication statusPublished - 11 Aug 2005
EventInternational Conference on Intelligent Computing, ICIC 2005 - Hefei, China
Duration: 23 Aug 200526 Aug 2005

Publication series

NameLecture Notes in Computer Science
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349
NameTheoretical Computer Science and General Issues
NameICIC: International Conference on Intelligent Computing


ConferenceInternational Conference on Intelligent Computing, ICIC 2005
Internet address

Scopus Subject Areas

  • Theoretical Computer Science
  • Computer Science(all)


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