An asymmetric ent-kauranoid dimer from Isodon rubescens var. lushanensis

Quan Bin Han, Yang Lu, Li Wu, Zhen Dan He, Chun Feng Qiao, Hong Xi Xu, Qi Tai Zheng, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

29 Citations (Scopus)


A novel asymmetric ent-kauranoid dimer, lushanrubescensin J (1), was isolated from Isodon rubescens var. lushanensis. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was confirmed by the single crystal X-ray diffraction of its tetraacetate. Compound (1) exhibited potent inhibitory activity against K562 cells with IC50 = 0.93 μg/mL.

Original languageEnglish
Pages (from-to)5373-5375
Number of pages3
JournalTetrahedron Letters
Issue number32
Publication statusPublished - 8 Aug 2005

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • ent-Kaurane dimer
  • Isodon rubescens var. lushanensis
  • Lushanrubescensin J
  • Tetraacetate


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