An asymmetric ent-kauranoid dimer from Isodon rubescens var. lushanensis

Quan Bin Han; Yang Lu; Li Wu; Zhen Dan He; Chun Feng Qiao; Hong Xi Xu; Qi Tai Zheng; Han Dong Sun

doi:10.1016/j.tetlet.2005.06.004

An asymmetric ent-kauranoid dimer from Isodon rubescens var. lushanensis

Quan Bin Han, Yang Lu, Li Wu, Zhen Dan He, Chun Feng Qiao, Hong Xi Xu, Qi Tai Zheng, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

29 Citations (Scopus)

Abstract

A novel asymmetric ent-kauranoid dimer, lushanrubescensin J (1), was isolated from Isodon rubescens var. lushanensis. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was confirmed by the single crystal X-ray diffraction of its tetraacetate. Compound (1) exhibited potent inhibitory activity against K562 cells with IC₅₀ = 0.93 μg/mL.

Original language	English
Pages (from-to)	5373-5375
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	32
DOIs	https://doi.org/10.1016/j.tetlet.2005.06.004
Publication status	Published - 8 Aug 2005

Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

User-Defined Keywords

ent-Kaurane dimer
Isodon rubescens var. lushanensis
Lushanrubescensin J
Tetraacetate

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10.1016/j.tetlet.2005.06.004

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@article{1d13573fa0a44e2d9a888bae23530b21,

title = "An asymmetric ent-kauranoid dimer from Isodon rubescens var. lushanensis",

abstract = "A novel asymmetric ent-kauranoid dimer, lushanrubescensin J (1), was isolated from Isodon rubescens var. lushanensis. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was confirmed by the single crystal X-ray diffraction of its tetraacetate. Compound (1) exhibited potent inhibitory activity against K562 cells with IC50 = 0.93 μg/mL.",

keywords = "ent-Kaurane dimer, Isodon rubescens var. lushanensis, Lushanrubescensin J, Tetraacetate",

author = "Han, {Quan Bin} and Yang Lu and Li Wu and He, {Zhen Dan} and Qiao, {Chun Feng} and Xu, {Hong Xi} and Zheng, {Qi Tai} and Sun, {Han Dong}",

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day = "8",

doi = "10.1016/j.tetlet.2005.06.004",

language = "English",

volume = "46",

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journal = "Tetrahedron Letters",

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TY - JOUR

T1 - An asymmetric ent-kauranoid dimer from Isodon rubescens var. lushanensis

AU - Han, Quan Bin

AU - Lu, Yang

AU - Wu, Li

AU - He, Zhen Dan

AU - Qiao, Chun Feng

AU - Xu, Hong Xi

AU - Zheng, Qi Tai

AU - Sun, Han Dong

PY - 2005/8/8

Y1 - 2005/8/8

N2 - A novel asymmetric ent-kauranoid dimer, lushanrubescensin J (1), was isolated from Isodon rubescens var. lushanensis. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was confirmed by the single crystal X-ray diffraction of its tetraacetate. Compound (1) exhibited potent inhibitory activity against K562 cells with IC50 = 0.93 μg/mL.

AB - A novel asymmetric ent-kauranoid dimer, lushanrubescensin J (1), was isolated from Isodon rubescens var. lushanensis. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was confirmed by the single crystal X-ray diffraction of its tetraacetate. Compound (1) exhibited potent inhibitory activity against K562 cells with IC50 = 0.93 μg/mL.

KW - ent-Kaurane dimer

KW - Isodon rubescens var. lushanensis

KW - Lushanrubescensin J

KW - Tetraacetate

UR - http://www.scopus.com/inward/record.url?scp=21844444318&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2005.06.004

DO - 10.1016/j.tetlet.2005.06.004

M3 - Journal article

SN - 0040-4039

VL - 46

SP - 5373

EP - 5375

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -

An asymmetric ent-kauranoid dimer from Isodon rubescens var. lushanensis

Abstract

Scopus Subject Areas

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