@article{c5cdd93bf3814c41aca892edda90c979,
title = "An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB",
abstract = "Four benzofuran-conjugated iridium(III) or rhodium (III)-based metal complexes are synthesized to screen as an inhibitor of STAT3 activity in prostate cancer cells. All complexes show the high stability and solubility in the biological system. In this study, an iridium(III) complex engages STAT3 and NF-κB to inhibit their translocation and transcriptional activities. Moreover, complex 1 shows more potential antiproliferative activity against DU145 cells and suppresses tumor growth in a prostate cancer xenograft mouse without observable adverse effects. Complex 1 may provide the basis for developing new therapeutic strategy in vivo and in vitro for the treatment of advanced prostate cancer.",
keywords = "Benzofuran-conjugated iridium(III) complex, Dual inhibitors, NF-κB, Prostate cells, STAT3",
author = "Kang, {Tian Shu} and Wanhe Wang and Zhong, {Hai Jing} and Dong, {Zhen Zhen} and Qi Huang and Mok, {Simon Wing Fai} and Leung, {Chung Hang} and Wong, {Vincent Kam Wai} and Ma, {Dik Lung}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/12301115, HKBU/204612 and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12-Oligoswitch), the Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund, Macao SAR (098/2014/A2) and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS) and the National Natural Science Foundation of China (No. 21628502). Publisher copyright: {\textcopyright} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = jun,
day = "28",
doi = "10.1016/j.canlet.2017.03.016",
language = "English",
volume = "396",
pages = "76--84",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
}