An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent

Chun Ting Poon; Pui Shan Chan; Cornelia Man; Feng Lei Jiang; Ricky N S WONG; Nai Ki MAK; Daniel W J KWONG; Sai Wah Tsao; Rick W K WONG

doi:10.1016/j.jinorgbio.2009.10.004

An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent

Chun Ting Poon
, Pui Shan Chan
, Cornelia Man
, Feng Lei Jiang
, Ricky N S WONG
, Nai Ki MAK^*
, Daniel W J KWONG
, Sai Wah Tsao
, Rick W K WONG

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

60 Citations (Scopus)

Abstract

An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.

Original language	English
Pages (from-to)	62-70
Number of pages	9
Journal	Journal of Inorganic Biochemistry
Volume	104
Issue number	1
DOIs	https://doi.org/10.1016/j.jinorgbio.2009.10.004
Publication status	Published - Jan 2010

User-Defined Keywords

Photodynamic therapy
Porphyroid
Ru(II)-polypyridyl
Tumor-imaging
Two-photon

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10.1016/j.jinorgbio.2009.10.004

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Poon, C. T., Chan, P. S., Man, C., Jiang, F. L., WONG, R. N. S., MAK, N. K., KWONG, D. W. J., Tsao, S. W., & WONG, R. W. K. (2010). An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent. Journal of Inorganic Biochemistry, 104(1), 62-70. https://doi.org/10.1016/j.jinorgbio.2009.10.004

@article{364bbf499caa434a8e3af15cd1f27ec1,

title = "An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent",

abstract = "An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.",

keywords = "Photodynamic therapy, Porphyroid, Ru(II)-polypyridyl, Tumor-imaging, Two-photon",

author = "Poon, \{Chun Ting\} and Chan, \{Pui Shan\} and Cornelia Man and Jiang, \{Feng Lei\} and WONG, \{Ricky N S\} and MAK, \{Nai Ki\} and KWONG, \{Daniel W J\} and Tsao, \{Sai Wah\} and WONG, \{Rick W K\}",

note = "Funding Information: The authors thank Prof. K.W. Cheah and Dr. H.L. Tam for their excellent technical support in the two-photon absorption cross-section measurements. This work was financially supported by Hong Kong Baptist University ( FRG/07-08/II-58 ) and three grants from the Hong Kong Research Grants Council (Grant Nos. HKBU2023/04P , HKBU 2458/06M and HKBU202308 ). ",

year = "2010",

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doi = "10.1016/j.jinorgbio.2009.10.004",

language = "English",

volume = "104",

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AU - Poon, Chun Ting

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AU - Man, Cornelia

AU - Jiang, Feng Lei

AU - WONG, Ricky N S

AU - MAK, Nai Ki

AU - KWONG, Daniel W J

AU - Tsao, Sai Wah

AU - WONG, Rick W K

N1 - Funding Information: The authors thank Prof. K.W. Cheah and Dr. H.L. Tam for their excellent technical support in the two-photon absorption cross-section measurements. This work was financially supported by Hong Kong Baptist University ( FRG/07-08/II-58 ) and three grants from the Hong Kong Research Grants Council (Grant Nos. HKBU2023/04P , HKBU 2458/06M and HKBU202308 ).

PY - 2010/1

Y1 - 2010/1

N2 - An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.

AB - An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.

KW - Photodynamic therapy

KW - Porphyroid

KW - Ru(II)-polypyridyl

KW - Tumor-imaging

KW - Two-photon

UR - https://www.scopus.com/pages/publications/70449678441

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DO - 10.1016/j.jinorgbio.2009.10.004

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SN - 0162-0134

VL - 104

SP - 62

EP - 70

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 1

ER -

An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent

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