An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent

Chun Ting Poon, Pui Shan Chan, Cornelia Man, Feng Lei Jiang, Ricky N S WONG, Nai Ki MAK*, Daniel W J KWONG, Sai Wah Tsao, Rick W K WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.

Original languageEnglish
Pages (from-to)62-70
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume104
Issue number1
DOIs
Publication statusPublished - Jan 2010

Scopus Subject Areas

  • Biochemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Photodynamic therapy
  • Porphyroid
  • Ru(II)-polypyridyl
  • Tumor-imaging
  • Two-photon

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