Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

Zhuoying Wu; Qianyi Luo; Huawang Wu; Zhiyao Wu; Yingjun Zheng; Yuling Yang; Jianfei He; Yi Ding; Rongjun Yu; Hongjun Peng

doi:10.3389/fpsyt.2020.596337

Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

Zhuoying Wu, Qianyi Luo, Huawang Wu, Zhiyao Wu, Yingjun Zheng, Yuling Yang, Jianfei He, Yi Ding, Rongjun Yu^*, Hongjun Peng^*

^*Corresponding author for this work

Academy of Wellness and Human Development

Research output: Contribution to journal › Journal article › peer-review

20 Citations (Scopus)

Abstract

Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.

Original language	English
Article number	596337
Number of pages	9
Journal	Frontiers in Psychiatry
Volume	11
DOIs	https://doi.org/10.3389/fpsyt.2020.596337
Publication status	Published - 22 Jan 2021

Scopus Subject Areas

Psychiatry and Mental health

User-Defined Keywords

childhood trauma
dorsal anterior cingulate cortex
insula
low-frequency fluctuation
major depressive disorder
MRI
primary somatosensory cortex
resting state

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fpsyt.2020.596337

Cite this

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title = "Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma",

abstract = "Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.",

keywords = "childhood trauma, dorsal anterior cingulate cortex, insula, low-frequency fluctuation, major depressive disorder, MRI, primary somatosensory cortex, resting state",

author = "Zhuoying Wu and Qianyi Luo and Huawang Wu and Zhiyao Wu and Yingjun Zheng and Yuling Yang and Jianfei He and Yi Ding and Rongjun Yu and Hongjun Peng",

note = "Funding Information: We would like to thank our subjects for their readiness to engage in this study. Funding. The Guangdong Natural Science Foundation, China (2015A030313800 to HP) supported the design of the study. The Guangzhou municipal key discipline in medicine for Guangzhou Brain Hospital (GBH2014-ZD04 to HP) supported the data collection of the study. The Science and Technology Plan Project of Guangdong Province, China (2019B030316001 to Yuping Ning) and the Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory (201805010009 to Yuping Ning) supported the interpretation of data of this study. Copyright {\textcopyright} 2021 Wu, Luo, Wu, Wu, Zheng, Yang, He, Ding, Yu and Peng.",

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doi = "10.3389/fpsyt.2020.596337",

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T1 - Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

AU - Wu, Zhuoying

AU - Luo, Qianyi

AU - Wu, Huawang

AU - Wu, Zhiyao

AU - Zheng, Yingjun

AU - Yang, Yuling

AU - He, Jianfei

AU - Ding, Yi

AU - Yu, Rongjun

AU - Peng, Hongjun

N1 - Funding Information: We would like to thank our subjects for their readiness to engage in this study. Funding. The Guangdong Natural Science Foundation, China (2015A030313800 to HP) supported the design of the study. The Guangzhou municipal key discipline in medicine for Guangzhou Brain Hospital (GBH2014-ZD04 to HP) supported the data collection of the study. The Science and Technology Plan Project of Guangdong Province, China (2019B030316001 to Yuping Ning) and the Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory (201805010009 to Yuping Ning) supported the interpretation of data of this study. Copyright © 2021 Wu, Luo, Wu, Wu, Zheng, Yang, He, Ding, Yu and Peng.

PY - 2021/1/22

Y1 - 2021/1/22

N2 - Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.

AB - Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.

KW - childhood trauma

KW - dorsal anterior cingulate cortex

KW - insula

KW - low-frequency fluctuation

KW - major depressive disorder

KW - MRI

KW - primary somatosensory cortex

KW - resting state

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DO - 10.3389/fpsyt.2020.596337

M3 - Journal article

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AN - SCOPUS:85100565136

SN - 1664-0640

VL - 11

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

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ER -

Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

Abstract

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