Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

Zhuoying Wu, Qianyi Luo, Huawang Wu, Zhiyao Wu, Yingjun Zheng, Yuling Yang, Jianfei He, Yi Ding, Rongjun YU, Hongjun Peng*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

16 Citations (Scopus)


Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.

Original languageEnglish
Article number596337
Number of pages9
JournalFrontiers in Psychiatry
Publication statusPublished - 22 Jan 2021

Scopus Subject Areas

  • Psychiatry and Mental health

User-Defined Keywords

  • childhood trauma
  • dorsal anterior cingulate cortex
  • insula
  • low-frequency fluctuation
  • major depressive disorder
  • MRI
  • primary somatosensory cortex
  • resting state


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