Amine-induced michael/conia-ene cascade reaction: Application to a formal synthesis of (±)-clavukerin a

Wei Li; Xiaozu Liu; Xiongfei Zhou; Chi Sing Lee

doi:10.1021/ol902567e

Amine-induced michael/conia-ene cascade reaction: Application to a formal synthesis of (±)-clavukerin a

Wei Li
, Xiaozu Liu
, Xiongfei Zhou
, Chi Sing Lee^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

34 Citations (Scopus)

Abstract

[Chemical equation presented] An efficient and versatile amine-induced Michael/Conia-ene cascade cyclization reaction has been developed for establishing 6,6- and 5,7-bicyclic fused carbocycles with simple acyclic β-ketoesters as the substrates In one-pot condition and this new cyclization method has been successfully utilized in a formal synthesis of (±)-Clavukerin A.

Original language	English
Pages (from-to)	548-551
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	3
Early online date	22 Dec 2009
DOIs	https://doi.org/10.1021/ol902567e
Publication status	Published - 5 Feb 2010

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@article{236aad552dbd465eb66ec86aa51518b7,

title = "Amine-induced michael/conia-ene cascade reaction: Application to a formal synthesis of (±)-clavukerin a",

abstract = "[Chemical equation presented] An efficient and versatile amine-induced Michael/Conia-ene cascade cyclization reaction has been developed for establishing 6,6- and 5,7-bicyclic fused carbocycles with simple acyclic β-ketoesters as the substrates In one-pot condition and this new cyclization method has been successfully utilized in a formal synthesis of (±)-Clavukerin A.",

author = "Wei Li and Xiaozu Liu and Xiongfei Zhou and Lee, \{Chi Sing\}",

note = "The financial support for this project from the National Natural Science Foundation of China (Grant No. 20672003) and the Peking University Shenzhen Graduate School is gratefully acknowledged. A special acknowledgment is made to the Hong Kong Polytechnic University, which is funded by the University Grants Committee of Hong Kong Special Equipment Grant, for the 500 and 600 MHz NMR spectrometers. Publisher Copyright: {\textcopyright} 2009 American Chemical Society ",

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doi = "10.1021/ol902567e",

language = "English",

volume = "12",

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journal = "Organic Letters",

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T1 - Amine-induced michael/conia-ene cascade reaction

T2 - Application to a formal synthesis of (±)-clavukerin a

AU - Li, Wei

AU - Liu, Xiaozu

AU - Zhou, Xiongfei

AU - Lee, Chi Sing

N1 - The financial support for this project from the National Natural Science Foundation of China (Grant No. 20672003) and the Peking University Shenzhen Graduate School is gratefully acknowledged. A special acknowledgment is made to the Hong Kong Polytechnic University, which is funded by the University Grants Committee of Hong Kong Special Equipment Grant, for the 500 and 600 MHz NMR spectrometers. Publisher Copyright: © 2009 American Chemical Society

PY - 2010/2/5

Y1 - 2010/2/5

N2 - [Chemical equation presented] An efficient and versatile amine-induced Michael/Conia-ene cascade cyclization reaction has been developed for establishing 6,6- and 5,7-bicyclic fused carbocycles with simple acyclic β-ketoesters as the substrates In one-pot condition and this new cyclization method has been successfully utilized in a formal synthesis of (±)-Clavukerin A.

AB - [Chemical equation presented] An efficient and versatile amine-induced Michael/Conia-ene cascade cyclization reaction has been developed for establishing 6,6- and 5,7-bicyclic fused carbocycles with simple acyclic β-ketoesters as the substrates In one-pot condition and this new cyclization method has been successfully utilized in a formal synthesis of (±)-Clavukerin A.

UR - https://www.scopus.com/pages/publications/75749102548

U2 - 10.1021/ol902567e

DO - 10.1021/ol902567e

M3 - Journal article

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AN - SCOPUS:75749102548

SN - 1523-7060

VL - 12

SP - 548

EP - 551

JO - Organic Letters

JF - Organic Letters

IS - 3

ER -

Amine-induced michael/conia-ene cascade reaction: Application to a formal synthesis of (±)-clavukerin a

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