TY - JOUR
T1 - Amelioration of experimental autoimmune encephalomyelitis by Rhodiola rosea, a natural adaptogen
AU - Lin, Xiuli
AU - Liu, Yingying
AU - Ma, Lili
AU - Ma, Xiaomeng
AU - Chen, Zhaoyu
AU - Chen, Hao
AU - Si, Lei
AU - Ma, Xueying
AU - Yu, Zhiling
AU - Chen, Xiaohong
N1 - Funding Information:
This work was supported by grants (to X Chen) from the National Natural Science Foundation of China (NSFC, No. 81971141 ), and the Israel Science Foundation (ISF) and the National Natural Science Foundation of China (NSFC) joint programme (No. 813111290 ).
PY - 2020/5
Y1 - 2020/5
N2 - Adaptogens are stress-response modifiers which have been considered to exert important influences on cytokines activities and immune response. Here, we investigated the effects of Rhodiola rosea (R. rosea), a natural adaptogen on the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We found that R. rosea alleviated the severity of EAE as evaluated by clinical and histopathology scores. R. rosea decreased IL-6, sIL-6R, IFN-γ and IL-17A in both serum and splenocytes supernatants while increased IL-4 in splenocytes supernatants of EAE mice. R. rosea also modulated the T cell response by inhibiting Th1 and Th17 cells, restoring Treg cells, combining with regulated Th17/Th1, Th17/Th2 and Th17/Treg ratios in the spleen, inguinal lymph nodes, brain and spinal cord of EAE mice. Furthermore, R. rosea regulated the expression of JAK1, JAK2, STAT3 and RORγt in the spinal cord of EAE mice. Together, our findings suggested the adaptogenic effects of R. rosea on EAE, which may help to deepen the understanding of potential therapeutic values of traditional Chinese medicines for autoimmune diseases of CNS.
AB - Adaptogens are stress-response modifiers which have been considered to exert important influences on cytokines activities and immune response. Here, we investigated the effects of Rhodiola rosea (R. rosea), a natural adaptogen on the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We found that R. rosea alleviated the severity of EAE as evaluated by clinical and histopathology scores. R. rosea decreased IL-6, sIL-6R, IFN-γ and IL-17A in both serum and splenocytes supernatants while increased IL-4 in splenocytes supernatants of EAE mice. R. rosea also modulated the T cell response by inhibiting Th1 and Th17 cells, restoring Treg cells, combining with regulated Th17/Th1, Th17/Th2 and Th17/Treg ratios in the spleen, inguinal lymph nodes, brain and spinal cord of EAE mice. Furthermore, R. rosea regulated the expression of JAK1, JAK2, STAT3 and RORγt in the spinal cord of EAE mice. Together, our findings suggested the adaptogenic effects of R. rosea on EAE, which may help to deepen the understanding of potential therapeutic values of traditional Chinese medicines for autoimmune diseases of CNS.
KW - Adaptogen
KW - Cytokines activities
KW - Experimental autoimmune encephalomyelitis
KW - Rhodiola rosea
KW - T cell response
UR - http://www.scopus.com/inward/record.url?scp=85079191888&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2020.109960
DO - 10.1016/j.biopha.2020.109960
M3 - Journal article
C2 - 32058218
AN - SCOPUS:85079191888
SN - 0753-3322
VL - 125
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 109960
ER -