Alternative Splicing, An Overlooked Defense Frontier of Plants with Respect to Bacterial Infection

Ji Qin Xie, Xiang Zhou, Zi Chang Jia, Chang Feng Su, Youjun Zhang, Alisdair R. Fernie, Jianhua Zhang*, Zhi Yan Du*, Mo Xian Chen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Disease represents a major problem in sustainable agricultural development. Plants interact closely with various microorganisms during their development and in response to the prevailing environment. In particular, pathogenic microorganisms can cause plant diseases, affecting the fertility, yield, and longevity of plants. During the long coevolution of plants and their pathogens, plants have evolved both molecular pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) signaling networks in order to regulate host cells in response to pathogen infestation. Additionally, in the postgenomic era, alternative splicing (AS) has become uncovered as one of the major drivers of proteome diversity, and abnormal RNA splicing is closely associated with bacterial infections. Currently, the complexity of host-bacteria interactions is a much studied area of research that has shown steady progress over the past decade. Although the development of high-throughput sequencing technologies and their application in transcriptomes have revolutionized our understanding of AS, many mechanisms related to host-bacteria interactions remain still unclear. To this end, this review summarizes the changes observed in AS during host-bacteria interactions and outlines potential therapeutics for bacterial diseases based on existing studies. In doing so, we hope to provide guidelines for plant disease management in agriculture.

Original languageEnglish
Pages (from-to)16883-16901
Number of pages19
JournalJournal of Agricultural and Food Chemistry
Early online date2 Nov 2023
DOIs
Publication statusPublished - 15 Nov 2023

Scopus Subject Areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

User-Defined Keywords

  • agrochemicals
  • Alternative splicing
  • cure
  • plant pathogens
  • plant−bacteria interaction

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