Alterations in acetylcholinesterase and choline acetyltransferase activities and neuropeptide levels in the ventral spinal cord of the Wobbler mouse during inherited motoneuron disease

Kin Lam Yung, F Tang, L.L. Vacca-Gallowaya*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Enymatic assays for acetylcholine esterase (AChE) and choline acetyltransferase (ChAT) were applied to dorsal and ventral cervical spinal cord regions taken from the Wobbler mouse, a model for inherited motoneuron disease. Early in the disease, ChAT (but not AChE) activity is significantly greater compared with the control littermate specimens. The high ChAT activity correlates with the high thyrotopin releasing hormone (also leucine-enkephalin) concentrations measured in the Wobbler ventral horn early in the disease. Late in the motoneuron disease, both AChE and ChAT activities are significantly lower than in the control littermate spicemens. These data correlate with the high substance P, methionine and leucine enkephalin concentrations measured in the Wobbler ventral horn late in the motoneuron disease.
Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalBrain Research
Volume638
Issue number1-2
DOIs
Publication statusPublished - 28 Feb 1994

User-Defined Keywords

  • Radioimmunoassay
  • Radioenzymatic assay
  • Wobbler mouse motoneuron disease
  • Cervical spinal cord
  • Acetylcholinesterase
  • Choline acetyltransferase
  • Thyrotropin-releasing hormone
  • Substance P
  • Methionine-enkephalin
  • Leucine-enkephalin

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