TY - JOUR
T1 - Alocasia cucullata Exhibits Strong Antitumor Effect In Vivo by Activating Antitumor Immunity
AU - Peng, Qiuxian
AU - Cai, Hongbing
AU - Sun, Xuegang
AU - Li, Xin
AU - Mo, Zhixian
AU - SHI, Jue
N1 - The work was supported by faculty research fund of HKBU #FRG2/09–10/019) to J. Shi, the Special Program for Key Basic Research of the Ministry of Science and Technology China (No. 2006CB708516) to Z. Mo and the Guangzhou Municipal research grant (#201300000152) to H. Cai. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PY - 2013/9/25
Y1 - 2013/9/25
N2 - Chinese herbal medicines have long been used to treat various illnesses by modulating the human immune response. In this study, we investigate the immuno-modulating effect and antitumor activity of Alocasia Cucullata (AC), a Chinese herb traditionally used to treat infection and cancer. We found that the whole water extract of AC roots could significantly attenuate tumor growth in mouse tumor models. The median survival time of the AC-treated mice was 43 days, 16 days longer than that of the control group. Moreover, the AC-treated mice showed substantially higher induction of key antitumor cytokines, such as IL-2, IFN-γ, and TNF-α, indicating that AC may exert antitumor effect by activating antitumor immunity. To further pinpoint the cellular and molecular mechanism of AC, we studied the dose response of a human monocytic cell line, THP-1, to the whole water extract of AC. Treatment of the AC extract significantly induced THP-1 differentiation into macrophage-like cells and the differentiated THP-1 showed expression of specific macrophage surface markers, such as CD11b and CD14, as well as productions of antitumor cytokines, e.g. IFN-γ and TNF-α. Our data thus point to AC as potentially a new, alternative immuno-modulating herbal remedy for anticancer treatment.
AB - Chinese herbal medicines have long been used to treat various illnesses by modulating the human immune response. In this study, we investigate the immuno-modulating effect and antitumor activity of Alocasia Cucullata (AC), a Chinese herb traditionally used to treat infection and cancer. We found that the whole water extract of AC roots could significantly attenuate tumor growth in mouse tumor models. The median survival time of the AC-treated mice was 43 days, 16 days longer than that of the control group. Moreover, the AC-treated mice showed substantially higher induction of key antitumor cytokines, such as IL-2, IFN-γ, and TNF-α, indicating that AC may exert antitumor effect by activating antitumor immunity. To further pinpoint the cellular and molecular mechanism of AC, we studied the dose response of a human monocytic cell line, THP-1, to the whole water extract of AC. Treatment of the AC extract significantly induced THP-1 differentiation into macrophage-like cells and the differentiated THP-1 showed expression of specific macrophage surface markers, such as CD11b and CD14, as well as productions of antitumor cytokines, e.g. IFN-γ and TNF-α. Our data thus point to AC as potentially a new, alternative immuno-modulating herbal remedy for anticancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=84884541984&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0075328
DO - 10.1371/journal.pone.0075328
M3 - Journal article
C2 - 24086508
AN - SCOPUS:84884541984
SN - 1932-6203
VL - 8
JO - PLoS ONE
JF - PLoS ONE
IS - 9
M1 - e75328
ER -
