TY - JOUR
T1 - Alcohol consumption by C57BL/6, BALB/c, and DBA/2 mice in a limited access paradigm
AU - Lê, AD
AU - Ko, J
AU - Chow, S
AU - Quan, B
PY - 1994/2
Y1 - 1994/2
N2 - Alcohol consumption by three inbred mice strains in a limited access condition was examined. Access to "Richter" tubes containing alcohol solution was restricted to 60 min per day in a drinking cage. Alcohol solution was given in escalating concentrations starting at 3% and ending at 12% w/v over several days. During the 12% phase, C57 mice consumed an average of 1.68 g/kg, while BALB and DBA mice consumed an average of 0.66 and 0.25 g/kg, respectively. The C57BL/6 mice achieved an average blood alcohol level (BAL) of 60 mg%, whereas the other two strains displayed negligible levels. The relationship between alcohol intake in a continuous and limited access as well as the utility of the limited access paradigm are discussed.
AB - Alcohol consumption by three inbred mice strains in a limited access condition was examined. Access to "Richter" tubes containing alcohol solution was restricted to 60 min per day in a drinking cage. Alcohol solution was given in escalating concentrations starting at 3% and ending at 12% w/v over several days. During the 12% phase, C57 mice consumed an average of 1.68 g/kg, while BALB and DBA mice consumed an average of 0.66 and 0.25 g/kg, respectively. The C57BL/6 mice achieved an average blood alcohol level (BAL) of 60 mg%, whereas the other two strains displayed negligible levels. The relationship between alcohol intake in a continuous and limited access as well as the utility of the limited access paradigm are discussed.
UR - http://europepmc.org/abstract/med/8146231
U2 - 10.1016/0091-3057(94)90026-4
DO - 10.1016/0091-3057(94)90026-4
M3 - Journal article
C2 - 8146231
SN - 0091-3057
VL - 47
SP - 375
EP - 378
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 2
ER -