Alboatisins A-C, ent-atisene diterpenoids from Isodon albopilosus

Sheng Xiong Huang; Yan Zhou; Li Bin Yang; Yong Zhao; Sheng Hong Li; Li Guang Lou; Quan Bin Han; Li Sheng Ding; Han Dong Sun

doi:10.1021/np070086a

Alboatisins A-C, ent-atisene diterpenoids from Isodon albopilosus

Sheng Xiong Huang, Yan Zhou, Li Bin Yang, Yong Zhao, Sheng Hong Li, Li Guang Lou, Quan Bin Han, Li Sheng Ding, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

21 Citations (Scopus)

Abstract

Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A-C (1-3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC₅₀ values of 8.3 and 7.9 μM, respectively.

Original language	English
Pages (from-to)	1053-1055
Number of pages	3
Journal	Journal of Natural Products
Volume	70
Issue number	6
Early online date	11 May 2007
DOIs	https://doi.org/10.1021/np070086a
Publication status	Published - 1 Jun 2007

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np070086a

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title = "Alboatisins A-C, ent-atisene diterpenoids from Isodon albopilosus",

abstract = "Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A-C (1-3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 μM, respectively.",

author = "Huang, {Sheng Xiong} and Yan Zhou and Yang, {Li Bin} and Yong Zhao and Li, {Sheng Hong} and Lou, {Li Guang} and Han, {Quan Bin} and Ding, {Li Sheng} and Sun, {Han Dong}",

note = "Financial support for this study was provided by the National Natural Science Foundation of China (No. 20502026 to Q.-B.H.) and the Natural Science Foundation of Yunnan Province (No. 2004C0008Z). The authors are grateful to Dr. F. Zhang for collecting the plant material.",

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doi = "10.1021/np070086a",

language = "English",

volume = "70",

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T1 - Alboatisins A-C, ent-atisene diterpenoids from Isodon albopilosus

AU - Huang, Sheng Xiong

AU - Zhou, Yan

AU - Yang, Li Bin

AU - Zhao, Yong

AU - Li, Sheng Hong

AU - Lou, Li Guang

AU - Han, Quan Bin

AU - Ding, Li Sheng

AU - Sun, Han Dong

N1 - Financial support for this study was provided by the National Natural Science Foundation of China (No. 20502026 to Q.-B.H.) and the Natural Science Foundation of Yunnan Province (No. 2004C0008Z). The authors are grateful to Dr. F. Zhang for collecting the plant material.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A-C (1-3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 μM, respectively.

AB - Three biogenetically interesting ent-kaurane-derived metabolites, alboatisins A-C (1-3), featuring a C-13-oxygenated ent-atisane skeleton, have been isolated from the aerial parts of Isodon albopilosus. Their structures were determined on the basis of spectroscopic evidence. Compound 2 exhibited cytotoxicity against A549 and HT-29 human cancer cells, with IC50 values of 8.3 and 7.9 μM, respectively.

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SN - 0163-3864

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ER -

Alboatisins A-C, ent-atisene diterpenoids from Isodon albopilosus

Abstract

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