TY - JOUR
T1 - Airborne Nanoplastics Exposure Inducing Irreversible Glucose Increase and Complete Hepatic Insulin Resistance
AU - Yang, Ziye
AU - Dong, Huajiang
AU - Gao, Yifei
AU - Liu, Shuang
AU - Chen, Long
AU - Ni, Guangjian
AU - Guo, Xiaoyu
AU - Wang, Meixue
AU - Wang, Can
AU - Chen, Yue
AU - Chen, Liqun
N1 - The authors thank Guangbo Qu at the Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, for the guidance and the technical support. This work was supported by the National Key Research and Development Program of China (grant no. 2022YFF1202900), the National Natural Science Foundation of China (grant nos. 31771100 and 32000815), the Science and Technology Projects of Tianjin (no. 21JCJQJC00080), the key technologies R & D program of Tianjin (no. 21JCZDJC00580), and the Tianjin Natural Science Foundation (no. 21JCYBJC01710).
Publisher Copyright:
© 2024 American Chemical Society.
PY - 2024/2/20
Y1 - 2024/2/20
N2 - As an emerging type of pollutant, microplastics have become a global
environmental problem. Approximately, a fifth of the global burden of
type 2 diabetes can be attributed to air particulate pollution. However,
scientific knowledge remains limited about the effects of airborne
nanoplastics (NPs) exposure on metabolic diseases. In this experiment, a
whole-body exposure system was used to simulate the real atmospheric
environment, and three exposure concentrations combined with the actual
environmental concentration were selected to explore the effects of
airborne NPs on metabolic diseases. Based on histological analyses,
metabolic studies, gene expression, metabolites, and molecular signaling
analyses, mice exposed to airborne NPs were observed to show a
phenotype of systemic inflammation and complete insulin resistance
featuring excessive drinking and eating, weight loss, elevated blood
glucose, and decreased triglyceride levels. After airborne NPs exposure,
mice were intolerant to glucose and tolerant to insulin. In addition,
airborne NPs exposure could result in long-term irreversible
hyperglycemia. Together, the research findings provide a strong basis
for understanding the hazards of airborne nanopollution on metabolic
disorders.
AB - As an emerging type of pollutant, microplastics have become a global
environmental problem. Approximately, a fifth of the global burden of
type 2 diabetes can be attributed to air particulate pollution. However,
scientific knowledge remains limited about the effects of airborne
nanoplastics (NPs) exposure on metabolic diseases. In this experiment, a
whole-body exposure system was used to simulate the real atmospheric
environment, and three exposure concentrations combined with the actual
environmental concentration were selected to explore the effects of
airborne NPs on metabolic diseases. Based on histological analyses,
metabolic studies, gene expression, metabolites, and molecular signaling
analyses, mice exposed to airborne NPs were observed to show a
phenotype of systemic inflammation and complete insulin resistance
featuring excessive drinking and eating, weight loss, elevated blood
glucose, and decreased triglyceride levels. After airborne NPs exposure,
mice were intolerant to glucose and tolerant to insulin. In addition,
airborne NPs exposure could result in long-term irreversible
hyperglycemia. Together, the research findings provide a strong basis
for understanding the hazards of airborne nanopollution on metabolic
disorders.
KW - airborne nanoplastics
KW - environmental exposure
KW - glucose metabolism
KW - insulin resistance
KW - multiomics analysis
UR - http://www.scopus.com/inward/record.url?scp=85187248864&partnerID=8YFLogxK
U2 - 10.1021/acs.est.3c06468
DO - 10.1021/acs.est.3c06468
M3 - Journal article
C2 - 38319870
AN - SCOPUS:85187248864
SN - 0013-936X
VL - 58
SP - 3108
EP - 3117
JO - Environmental Science and Technology
JF - Environmental Science and Technology
IS - 7
ER -
