Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy

Chao Zhao, Peisi Xie, Ting Yong, Wei Huang, Jianjun Liu, Desheng Wu, Fenfen Ji, Min LI, Doudou Zhang, Ruijin Li, Chuan Dong, Juan Ma, Zheng Dong, Sijin Liu, Zongwei CAI*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Gestational exposure to PM2.5 is associated with adverse postnatal outcomes. PM2.5 can enter alveoli by using intratracheal instillation, even penetrate through lung cells into the blood circulation. Subsequently, they are transferred across the placenta and fetal blood brain barrier, causing the adverse birth outcomes of offspring. This study demonstrated that the gestational exposure resulted in cognitive and emotional disorders in female offspring although the offspring were not exposed to PM2.5. Placental metabolic pathways modulated fetal brain development and played a pivotal role for maternal-placental-fetal interactions in the fetal programming of adult behavioral and mental disorders. Samples of fetus, offspring hippocampus and placenta from the mice exposed to PM2.5 were investigated using a comprehensive approach including mass spectrometry-based lipidomics and three-dimensional imaging. The exposure induced the neuro-degeneration in hippocampus, impairment of placental cytoarchitecture, and reprogramming of lipidome, which might affect the modulation of maternal-fetal cross-talk and result in the behavior disorders of offspring. The variation of spatial distribution of lipids was profoundly affected in dorsal pallium and hippocampal formation regions of fetal brain, offspring hippocampus, as well as labyrinth and junctional zones of placenta. The abundance alteration of lipid markers associated with neurodegenerative diseases was validated in transgenic mouse model with Alzheimer's disease and human cerebrospinal fluid from patients with Parkinson's disease. The finding could help with the selection of more suitable heterogeneous-related substructures targeting PM2.5 exposure and the exploration of PM2.5-induced toxicological effects on neurodegenerative diseases.

Original languageEnglish
Pages (from-to)578-591
Number of pages14
JournalScience Bulletin
Volume66
Issue number6
DOIs
Publication statusPublished - 30 Mar 2021

Scopus Subject Areas

  • General

User-Defined Keywords

  • Airborne fine particulate matter
  • Cognitive and emotional disorders
  • Gestational exposure
  • Lipid metabolism
  • Mass spectrometry imaging

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