TY - JOUR
T1 - Aged mesenchymal stem cells and inflammation
T2 - from pathology to potential therapeutic strategies
AU - Yang, Xue
AU - Wang, Ying
AU - Rovella, Valentina
AU - Candi, Eleonora
AU - Jia, Wei
AU - Bernassola, Francesca
AU - Bove, Pierluigi
AU - Piacentini, Mauro
AU - Scimeca, Manuel
AU - Sica, Giuseppe
AU - Tisone, Giuseppe
AU - Mauriello, Alessandro
AU - Wei, Lixin
AU - Melino, Gerry
AU - Shi, Yufang
N1 - Funding information:
This study has received funding from the European Union NextGenerationEU through the Italian Ministry of University and Research under PNRR-MAC2-II.3 project PE6 “Heal Italia" to GM, EC, MP and FB) CUP E83C22004670001; and partially by Associazione Italiana per la Ricerca contro il Cancro [AIRC] to GM [IG 2022 ID 27366; 2023–2027], or to EC [IG#22206; 2019–2023]. Work has been also partially supported by Regione Lazio through LazioInnova Progetto Gruppo di Ricerca n 85-2017-14986; n 33 & 55-2021-T0002E0001.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/7/18
Y1 - 2023/7/18
N2 - Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC application is not satisfactory for some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered cell population reduction and differentiation ability, reduced migratory and homing capacity and, most important, defective immunosuppression. It is necessary to explore the relationship between the “inflammaging” and aged MSCs to prevent age-related diseases and increase the therapeutic effects of MSCs. In this review, we discuss changes in naturally ageing MSCs mainly from an inflammation perspective and propose some ideas for rejuvenating aged MSCs in future treatments.
AB - Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC application is not satisfactory for some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered cell population reduction and differentiation ability, reduced migratory and homing capacity and, most important, defective immunosuppression. It is necessary to explore the relationship between the “inflammaging” and aged MSCs to prevent age-related diseases and increase the therapeutic effects of MSCs. In this review, we discuss changes in naturally ageing MSCs mainly from an inflammation perspective and propose some ideas for rejuvenating aged MSCs in future treatments.
KW - Inflammation
KW - Mesenchymal stem cells
KW - MSC Therapy
UR - http://www.scopus.com/inward/record.url?scp=85165265515&partnerID=8YFLogxK
U2 - 10.1186/s13062-023-00394-6
DO - 10.1186/s13062-023-00394-6
M3 - Review article
C2 - 37464416
AN - SCOPUS:85165265515
SN - 1745-6150
VL - 18
JO - Biology Direct
JF - Biology Direct
M1 - 40
ER -
