@article{56b3655f3b1143b29a8637d40bdce300,
title = "Affinity-Based Luminescent Iridium(III) Complexes for the Detection of Disease-Related Proteins",
abstract = "The occurrence of diseases is usually accompanied by changes in protein levels and types. These differentially expressed proteins can be used as biomarkers for the diagnosis and treatment of diseases. In recent years, luminescent iridium(III) complexes have attracted much attention in the field of protein-based disease diagnosis due to their excellent optical properties. In particular, affinity-based luminescent iridium(III) complexes have the advantage of evaluating protein information with minimal interference on their biological activities. In this review, we summarize the current advances in affinity-based luminescent iridium(III) complexes for the detection of disease-related proteins. Moreover, the future perspective for affinity-based iridium(III) complexes is discussed.",
keywords = "affinity-based probe, cancer, diagnosis, iridium(III) complexes, luminescence, protein biomarkers",
author = "Wanhe Wang and Jianhua Liu and Nao, {Sang Cuo} and Ma, {Dik Lung} and Jing Wang and Leung, {Chung Hang}",
note = "This research was funded by the Natural Science Basic Research Program of Shaanxi (2021JQ-089, 2021JQ-092), the Natural Science Foundation of Chongqing, China (cstc2021jcyj-msxmX0659), the National Natural Science Foundation of China (22101230), the Fundamental Research Funds for the Central Universities (31020200QD017, 31020200QD023), Shanghai Sailing Program (21YF1451200), the Guangdong Basic and Applied Basic Research Foundation (2021A1515110840), Hainan Province Science and Technology Special Fund (ZDYF2021SHFZ250), the Science and Technology Development Fund, Macau SAR (0007/2020/A1, 0020/2022/A1), SKL-QRCM(UM)-2020-2022, QRCM-IRG2022-011, and the University of Macau (MYRG2019-00002-ICMS, MYRG2020-00017-ICMS). Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
month = oct,
day = "25",
doi = "10.3390/inorganics10110178",
language = "English",
volume = "10",
journal = "Inorganics",
issn = "2304-6740",
publisher = "MDPI",
number = "11",
}
