Affinity-Based Luminescent Iridium(III) Complexes for the Detection of Disease-Related Proteins

Wanhe Wang; Jianhua Liu; Sang Cuo Nao; Dik Lung Ma; Jing Wang; Chung Hang Leung

doi:10.3390/inorganics10110178

Affinity-Based Luminescent Iridium(III) Complexes for the Detection of Disease-Related Proteins

Wanhe Wang^*, Jianhua Liu, Sang Cuo Nao, Dik Lung Ma, Jing Wang^*, Chung Hang Leung^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

The occurrence of diseases is usually accompanied by changes in protein levels and types. These differentially expressed proteins can be used as biomarkers for the diagnosis and treatment of diseases. In recent years, luminescent iridium(III) complexes have attracted much attention in the field of protein-based disease diagnosis due to their excellent optical properties. In particular, affinity-based luminescent iridium(III) complexes have the advantage of evaluating protein information with minimal interference on their biological activities. In this review, we summarize the current advances in affinity-based luminescent iridium(III) complexes for the detection of disease-related proteins. Moreover, the future perspective for affinity-based iridium(III) complexes is discussed.

Original language	English
Article number	178
Number of pages	16
Journal	Inorganics
Volume	10
Issue number	11
DOIs	https://doi.org/10.3390/inorganics10110178
Publication status	Published - 25 Oct 2022

Scopus Subject Areas

Inorganic Chemistry

User-Defined Keywords

affinity-based probe
cancer
diagnosis
iridium(III) complexes
luminescence
protein biomarkers

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/inorganics10110178

Cite this

@article{56b3655f3b1143b29a8637d40bdce300,

title = "Affinity-Based Luminescent Iridium(III) Complexes for the Detection of Disease-Related Proteins",

abstract = "The occurrence of diseases is usually accompanied by changes in protein levels and types. These differentially expressed proteins can be used as biomarkers for the diagnosis and treatment of diseases. In recent years, luminescent iridium(III) complexes have attracted much attention in the field of protein-based disease diagnosis due to their excellent optical properties. In particular, affinity-based luminescent iridium(III) complexes have the advantage of evaluating protein information with minimal interference on their biological activities. In this review, we summarize the current advances in affinity-based luminescent iridium(III) complexes for the detection of disease-related proteins. Moreover, the future perspective for affinity-based iridium(III) complexes is discussed.",

keywords = "affinity-based probe, cancer, diagnosis, iridium(III) complexes, luminescence, protein biomarkers",

author = "Wanhe Wang and Jianhua Liu and Nao, {Sang Cuo} and Ma, {Dik Lung} and Jing Wang and Leung, {Chung Hang}",

note = "This research was funded by the Natural Science Basic Research Program of Shaanxi (2021JQ-089, 2021JQ-092), the Natural Science Foundation of Chongqing, China (cstc2021jcyj-msxmX0659), the National Natural Science Foundation of China (22101230), the Fundamental Research Funds for the Central Universities (31020200QD017, 31020200QD023), Shanghai Sailing Program (21YF1451200), the Guangdong Basic and Applied Basic Research Foundation (2021A1515110840), Hainan Province Science and Technology Special Fund (ZDYF2021SHFZ250), the Science and Technology Development Fund, Macau SAR (0007/2020/A1, 0020/2022/A1), SKL-QRCM(UM)-2020-2022, QRCM-IRG2022-011, and the University of Macau (MYRG2019-00002-ICMS, MYRG2020-00017-ICMS). Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

day = "25",

doi = "10.3390/inorganics10110178",

language = "English",

volume = "10",

journal = "Inorganics",

issn = "2304-6740",

publisher = "MDPI",

number = "11",

}

TY - JOUR

T1 - Affinity-Based Luminescent Iridium(III) Complexes for the Detection of Disease-Related Proteins

AU - Wang, Wanhe

AU - Liu, Jianhua

AU - Nao, Sang Cuo

AU - Ma, Dik Lung

AU - Wang, Jing

AU - Leung, Chung Hang

N1 - This research was funded by the Natural Science Basic Research Program of Shaanxi (2021JQ-089, 2021JQ-092), the Natural Science Foundation of Chongqing, China (cstc2021jcyj-msxmX0659), the National Natural Science Foundation of China (22101230), the Fundamental Research Funds for the Central Universities (31020200QD017, 31020200QD023), Shanghai Sailing Program (21YF1451200), the Guangdong Basic and Applied Basic Research Foundation (2021A1515110840), Hainan Province Science and Technology Special Fund (ZDYF2021SHFZ250), the Science and Technology Development Fund, Macau SAR (0007/2020/A1, 0020/2022/A1), SKL-QRCM(UM)-2020-2022, QRCM-IRG2022-011, and the University of Macau (MYRG2019-00002-ICMS, MYRG2020-00017-ICMS). Publisher Copyright: © 2022 by the authors.

PY - 2022/10/25

Y1 - 2022/10/25

N2 - The occurrence of diseases is usually accompanied by changes in protein levels and types. These differentially expressed proteins can be used as biomarkers for the diagnosis and treatment of diseases. In recent years, luminescent iridium(III) complexes have attracted much attention in the field of protein-based disease diagnosis due to their excellent optical properties. In particular, affinity-based luminescent iridium(III) complexes have the advantage of evaluating protein information with minimal interference on their biological activities. In this review, we summarize the current advances in affinity-based luminescent iridium(III) complexes for the detection of disease-related proteins. Moreover, the future perspective for affinity-based iridium(III) complexes is discussed.

AB - The occurrence of diseases is usually accompanied by changes in protein levels and types. These differentially expressed proteins can be used as biomarkers for the diagnosis and treatment of diseases. In recent years, luminescent iridium(III) complexes have attracted much attention in the field of protein-based disease diagnosis due to their excellent optical properties. In particular, affinity-based luminescent iridium(III) complexes have the advantage of evaluating protein information with minimal interference on their biological activities. In this review, we summarize the current advances in affinity-based luminescent iridium(III) complexes for the detection of disease-related proteins. Moreover, the future perspective for affinity-based iridium(III) complexes is discussed.

KW - affinity-based probe

KW - cancer

KW - diagnosis

KW - iridium(III) complexes

KW - luminescence

KW - protein biomarkers

UR - http://www.scopus.com/inward/record.url?scp=85141782759&partnerID=8YFLogxK

U2 - 10.3390/inorganics10110178

DO - 10.3390/inorganics10110178

M3 - Review article

AN - SCOPUS:85141782759

SN - 2304-6740

VL - 10

JO - Inorganics

JF - Inorganics

IS - 11

M1 - 178

ER -

Affinity-Based Luminescent Iridium(III) Complexes for the Detection of Disease-Related Proteins

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

Access to Document

Other files and links

Cite this