Advances of MALDI-TOF MS in the Analysis of Traditional Chinese Medicines

Minghua Lu; Zongwei Cai

doi:10.1007/128_2012_383

Advances of MALDI-TOF MS in the Analysis of Traditional Chinese Medicines

Minghua Lu, Zongwei Cai^*

^*Corresponding author for this work

Department of Chemistry

Research output: Chapter in book/report/conference proceeding › Chapter › peer-review

24 Citations (Scopus)

Abstract

Traditional Chinese medicines (TCMs) are attracting more and more attention because of their long historical clinical experience and reliable therapeutic efficacy for preventing and/or treating various human diseases. Many techniques and methods were developed for the analysis of TCMs to support new drug discovery and quality control. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), a soft ionization mass spectrometric technique, has been widely used in the analysis of a wide variety of large molecular compounds including proteins, peptides, and polymers since it was introduced in the late 1980s. In the present chapter, advances of MALDI-TOF MS in TCMs analysis have been reviewed. The review covers MALDI-TOF MS applications in the identification of new bioactive ingredients, analysis of alkaloids, determination of small molecular compounds with new matrices, proteomics analysis associated with TCMs, direct analysis of plant tissue, and other applications in TCMs.

Original language	English
Title of host publication	Applications of MALDI-TOF Spectroscopy
Editors	Zongwei Cai, Shuying Liu
Publisher	Springer Berlin Heidelberg
Pages	143-164
Number of pages	22
Edition	1st
ISBN (Electronic)	9783642356650
ISBN (Print)	9783642356643, 9783642444524
DOIs	https://doi.org/10.1007/128_2012_383
Publication status	Published - 25 Oct 2012

Publication series

Name	Topics in Current Chemistry
Volume	331
ISSN (Print)	0340-1022
ISSN (Electronic)	1436-5049

Scopus Subject Areas

Chemistry(all)

User-Defined Keywords

Chinese herbs
MALDI-TOF MS
Traditional Chinese medicines (TCMs)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/128_2012_383

Cite this

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Advances of MALDI-TOF MS in the Analysis of Traditional Chinese Medicines

Abstract

Publication series

Scopus Subject Areas

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UN SDGs

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