Advances of MALDI-TOF MS in the analysis of traditional Chinese medicines

Minghua Lu, Zongwei CAI*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

16 Citations (Scopus)

Abstract

Traditional Chinese medicines (TCMs) are attracting more and more attention because of their long historical clinical experience and reliable therapeutic efficacy for preventing and/or treating various human diseases. Many techniques and methods were developed for the analysis of TCMs to support new drug discovery and quality control. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), a soft ionization mass spectrometric technique, has been widely used in the analysis of a wide variety of large molecular compounds including proteins, peptides, and polymers since it was introduced in the late 1980s. In the present chapter, advances of MALDI-TOF MS in TCMs analysis have been reviewed. The review covers MALDI-TOF MS applications in the identification of new bioactive ingredients, analysis of alkaloids, determination of small molecular compounds with new matrices, proteomics analysis associated with TCMs, direct analysis of plant tissue, and other applications in TCMs.

Original languageEnglish
Title of host publicationApplications of MALDI-TOF Spectroscopy
EditorsZongwei Cai, Shuying Liu
PublisherSpringer Verlag
Pages143-164
Number of pages22
ISBN (Electronic)9783642356650
ISBN (Print)9783642356643, 9783642444524
DOIs
Publication statusPublished - 2013

Publication series

NameTopics in Current Chemistry
Volume331
ISSN (Print)0340-1022

Scopus Subject Areas

  • Chemistry(all)

User-Defined Keywords

  • Chinese herbs
  • MALDI-TOF MS
  • Traditional Chinese medicines (TCMs)

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