Advanced mass spectrometry-based multi-omics technologies for exploring the pathogenesis of hepatocellular carcinoma

Wenna Nie, Leyu Yan, Yie H. Lee, Chandan Guha, Irwin J. Kurland, Haitao Lu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)


Hepatocellular carcinoma (HCC) is one of the primary hepatic malignancies and is the third most common cause of cancer related death worldwide. Although a wealth of knowledge has been gained concerning the initiation and progression of HCC over the last half century, efforts to improve our understanding of its pathogenesis at a molecular level are still greatly needed, to enable clinicians to enhance the standards of the current diagnosis and treatment of HCC. In the post-genome era, advanced mass spectrometry driven multi-omics technologies (e.g., profiling of DNA damage adducts, RNA modification profiling, proteomics, and metabolomics) stand at the interface between chemistry and biology, and have yielded valuable outcomes from the study of a diversity of complicated diseases. Particularly, these technologies are being broadly used to dissect various biological aspects of HCC with the purpose of biomarker discovery, interrogating pathogenesis as well as for therapeutic discovery. This proof of knowledge-based critical review aims at exploring the selected applications of those defined omics technologies in the HCC niche with an emphasis on translational applications driven by advanced mass spectrometry, toward the specific clinical use for HCC patients. This approach will enable the biomedical community, through both basic research and the clinical sciences, to enhance the applicability of mass spectrometry-based omics technologies in dissecting the pathogenesis of HCC and could lead to novel therapeutic discoveries for HCC.

Original languageEnglish
Pages (from-to)331-349
Number of pages19
JournalMass Spectrometry Reviews
Issue number3
Early online date2 Jun 2014
Publication statusPublished - May 2016

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Condensed Matter Physics
  • Spectroscopy

User-Defined Keywords

  • DNA damage adducts
  • hepatocellular carcinoma
  • metabolomics
  • omics technology
  • proteomics
  • RNA modifications


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