TY - JOUR
T1 - Adjuvant phytotherapy in the treatment of cervical cancer
T2 - A systematic review and meta-analysis
AU - Xu, Min
AU - Deng, Ping Xiang
AU - Qi, Chen
AU - Deng, Bin
AU - Zhao, Zhong Zhen
AU - Wong, Vivian
AU - Ngan, Teresa
AU - Kan, Vincent
AU - Tian, Xiao Ying
AU - Xu, Dong Ying
AU - Au, Dawn
N1 - Funding information:
This project was supported by a grant of the Hospital Authority of Hong Kong (HOC172-06) and a grant of Hong Kong Baptist University (FRG/07-08/I-37).
Publisher copyright:
© MaryAnnLiebert, Inc.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Objective: Clinical trials have investigated phytotherapy (PT) in the treatment of cervical cancer. This study aimed to assess the quality and data of current available trials, to compare the efficacy and safety of conventional therapies (CT) including surgical therapy, radiotherapy, and chemotherapy with that of CT plus PT (CT-PT), and to identify herbs used commonly in clinical trials. Methods: Forty-three (43) electronic databases were searched. The quality of eligible trials was assessed by Jadad's scale, and Revman 5.0 software was used for data syntheses and analyses. Result: (1) Of the 48 potential trials retrieved, 18 trials involving 1657 patients met the inclusion criteria, and two trials were graded as high-quality trials; (2) CT-PT achieved a higher 1-year survival rate (SR, p=0.0002) and tumor remission rate (TRR, p<0.0001) than CT alone; (3) PT showed therapeutic effects comparable to those of Western medications in diminishing vesical complications (VC, p<0.0001) and rectal complications (RC, p=0.08) caused by CT; (4) top 15 herbs used frequently to improve SR or TRR and to treat VC or RC in the retrieved trials were identified. Conclusions: Adjuvant PT may improve the efficacy and safety of CT in clinical treatments of cervical cancer, although this result needs to be further verified by more high-quality trials.
AB - Objective: Clinical trials have investigated phytotherapy (PT) in the treatment of cervical cancer. This study aimed to assess the quality and data of current available trials, to compare the efficacy and safety of conventional therapies (CT) including surgical therapy, radiotherapy, and chemotherapy with that of CT plus PT (CT-PT), and to identify herbs used commonly in clinical trials. Methods: Forty-three (43) electronic databases were searched. The quality of eligible trials was assessed by Jadad's scale, and Revman 5.0 software was used for data syntheses and analyses. Result: (1) Of the 48 potential trials retrieved, 18 trials involving 1657 patients met the inclusion criteria, and two trials were graded as high-quality trials; (2) CT-PT achieved a higher 1-year survival rate (SR, p=0.0002) and tumor remission rate (TRR, p<0.0001) than CT alone; (3) PT showed therapeutic effects comparable to those of Western medications in diminishing vesical complications (VC, p<0.0001) and rectal complications (RC, p=0.08) caused by CT; (4) top 15 herbs used frequently to improve SR or TRR and to treat VC or RC in the retrieved trials were identified. Conclusions: Adjuvant PT may improve the efficacy and safety of CT in clinical treatments of cervical cancer, although this result needs to be further verified by more high-quality trials.
UR - http://www.scopus.com/inward/record.url?scp=73149108663&partnerID=8YFLogxK
U2 - 10.1089/acm.2009.0202
DO - 10.1089/acm.2009.0202
M3 - Journal article
C2 - 19954338
AN - SCOPUS:73149108663
SN - 1075-5535
VL - 15
SP - 1347
EP - 1353
JO - Journal of Alternative and Complementary Medicine
JF - Journal of Alternative and Complementary Medicine
IS - 12
ER -
