Adjuvant phytotherapy in the treatment of cervical cancer: A systematic review and meta-analysis

Min Xu*, Ping Xiang Deng, Chen Qi, Bin Deng, Zhong Zhen Zhao, Vivian Wong, Teresa Ngan, Vincent Kan, Xiao Ying Tian, Dong Ying Xu, Dawn Au

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

7 Citations (Scopus)
5 Downloads (Pure)

Abstract

Objective: Clinical trials have investigated phytotherapy (PT) in the treatment of cervical cancer. This study aimed to assess the quality and data of current available trials, to compare the efficacy and safety of conventional therapies (CT) including surgical therapy, radiotherapy, and chemotherapy with that of CT plus PT (CT-PT), and to identify herbs used commonly in clinical trials. Methods: Forty-three (43) electronic databases were searched. The quality of eligible trials was assessed by Jadad's scale, and Revman 5.0 software was used for data syntheses and analyses. Result: (1) Of the 48 potential trials retrieved, 18 trials involving 1657 patients met the inclusion criteria, and two trials were graded as high-quality trials; (2) CT-PT achieved a higher 1-year survival rate (SR, p=0.0002) and tumor remission rate (TRR, p<0.0001) than CT alone; (3) PT showed therapeutic effects comparable to those of Western medications in diminishing vesical complications (VC, p<0.0001) and rectal complications (RC, p=0.08) caused by CT; (4) top 15 herbs used frequently to improve SR or TRR and to treat VC or RC in the retrieved trials were identified. Conclusions: Adjuvant PT may improve the efficacy and safety of CT in clinical treatments of cervical cancer, although this result needs to be further verified by more high-quality trials.

Original languageEnglish
Pages (from-to)1347-1353
Number of pages7
JournalJournal of Alternative and Complementary Medicine
Volume15
Issue number12
DOIs
Publication statusPublished - 1 Dec 2009

Scopus Subject Areas

  • Complementary and alternative medicine

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