Adjusted indirect and mixed comparisons of interventions for the patient-reported outcomes measures (Proms) of disabled adults: A systematic review and network meta-analysis

Yining Xu, Xin Li, Zhihong Sun, Yang Song, Julien BAKER*, Yaodong Gu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

This systematic review adopted the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) guidelines and used the method of network meta-analysis to compare the effects of different types of interventions from different perspectives which were abilities of daily life activity, psychological health, social functioning, and overall life quality. The eligi-bility criteria were: (1) Participants were adults above 18 years old with disabilities; (2) Interventions could be classified into active exercise, passive therapy, psychological education, psychosocial support program, multi-disciplinary program, and usual care; (3) Outcomes should be the patient-re-ported outcome measures (PROMs) that could be classified into abilities of daily life activity, psychological health, social functioning, and overall life quality; (4) Randomized designed and pub-lished in English. The keywords and their search field were: (1) “people with disabilities/disability”, “disabled”, “handicapped”, or “disable people” in titles or abstracts; (2) AND “randomized” or “randomised” in titles or abstracts; (3) NOT ”design”, “protocol”, or “review” in titles. After search-ing in databases of Medline (EBSCO), PubMed, CINAHL, and Ovid, 16 studies were included. As a result, active exercise and passive therapy are most likely to be the best interventions for overall life quality, psychological education and passive therapy are most likely to be the best interventions for abilities of daily life activity, and psychosocial support programs are most likely to be the best intervention for psychological health and social functioning.

Original languageEnglish
Article number2406
Pages (from-to)1-28
Number of pages28
JournalInternational Journal of Environmental Research and Public Health
Volume18
Issue number5
DOIs
Publication statusPublished - 1 Mar 2021

Scopus Subject Areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Disabled
  • Handicap
  • Network meta-analysis
  • Patient-reported outcome measures
  • People with disabilities

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