Adaptive gastric mucosal cytoprotection in rats: Different modes of action by three mild irritants

J. K.S. Ko, C. H. Cho*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

5 Citations (Scopus)


The mechanisms of adaptive mucosal cytoprotection by mild irritants were investigated in rats. In an ex vivo chamber preparation, application of 20% ethanol, 5% NaCl or 0.3 M ΗCl to the posterior side of the mucosa significantly protected that side of the stomach against mucosal damage caused by subsequent exposure to 100% ethanol, with contralateral transmission of protection to the anterior side by 20% ethanol and 0.3 M HCl. Atropine or lidocaine significantly reversed the cytoprotection of 20% ethanol. Bilateral vagotomy partially prevented the antilesion action of 20% ethanol, and completely prevented the action of 0.3 M HCl. However, the three mild irritants did not affect gastric mucosal blood flow, but restored the ion transport mechanism which was depressed by ethanol. It is therefore concluded that the three mild irritants have their own distinctive cytoprotective mechanisms against ethanol ulceration, which is predominantly not mediated by effects on the vascular system of the gastric mucosa.

Original languageEnglish
Pages (from-to)54-59
Number of pages6
Issue number1
Publication statusPublished - 1 Jan 1996

Scopus Subject Areas

  • Gastroenterology

User-Defined Keywords

  • Adaptive mucosal cytoprotection
  • Blood flow
  • Ethanol
  • Gastric lesions
  • Ion fluxes
  • Mild irritants


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