Acupuncture at Waiguan (TE5) influences activation/deactivation of functional brain areas in ischemic stroke patients and healthy people: A functional MRI study

Jun Qi Chen, Yong Huang*, Xin Sheng Lai, Chun Zhi Tang, Junjun YANG, Hua Chen, Tong Jun Zeng, Jun Xian Wu, Shan Shan Qu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In the present study, 10 patients with ischemic stroke in the left hemisphere and six healthy controls were subjected to acupuncture at right Waiguan (TE5). In ischemic stroke subjects, functional MRI showed enhanced activation in Broadmann areas 5, 6, 7, 18, 19, 24, 32, the hypothalamic inferior lobe, the mamillary body, and the ventral posterolateral nucleus of the left hemisphere, and Broadmann areas 4, 6, 7, 18, 19 and 32 of the right hemisphere, but attenuated activation of Broadmann area 13, the hypothalamic inferior lobe, the posterior lobe of the tonsil of cerebellum, and the culmen of the anterior lobe of hypophysis, in the left hemisphere and Broadmann area 13 in the right hemisphere. In ischemic stroke subjects, a number of deactivated brain areas were enhanced, including Broadmann areas 6, 11, 20, 22, 37, and 47, the culmen of the anterior lobe of hypophysis, alae lingulae cerebella, and the posterior lobe of the tonsil of cerebellum of the left hemisphere, and Broadmann areas 8, 37, 45 and 47, the culmen of the anterior lobe of hypophysis, pars tuberalis adenohypophyseos, inferior border of lentiform nucleus, lateral globus pallidus, inferior temporal gyrus, and the parahippocampal gyrus of the right hemisphere. These subjects also exhibited attenuation of a number of deactivated brain areas, including Broadmann area 7. These data suggest that acupuncture at Waiguan specifically alters brain function in regions associated with sensation, vision, and motion in ischemic stroke patients. By contrast, in normal individuals, acupuncture at Waiguan generally activates brain areas associated with insomnia and other functions.

Original languageEnglish
Pages (from-to)226-232
Number of pages7
JournalNeural Regeneration Research
Volume8
Issue number3
DOIs
Publication statusPublished - 25 Jan 2013

Scopus Subject Areas

  • Developmental Neuroscience

User-Defined Keywords

  • Acupuncture
  • Acupuncture and moxibustion
  • Cerebral function imaging
  • Functional MRI
  • Grants-supported paper
  • Ischemic stroke
  • Motion brain areas
  • Neural regeneration
  • Neuroregeneration
  • Photographs-containing paper
  • Specificity of acupoints
  • Waiguan (TE5)

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