Acupuncture at the Taixi (KI3) acupoint activates cerebral neurons in elderly patients with mild cognitive impairment

Shang Jie Chen, Mao Sheng Xu, Hong LI, Jiu Ping Liang, Liang Yin, Xia Liu, Xin Yan Jia, Fen Zhu, Dan Wang, Xue Min Shi, Li Hua Zhao

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Our previous findings have demonstrated that acupuncture at the Taixi (KI3) acupoint in healthy youths can activate neurons in cognitive-related cerebral cortex. Here, we investigated whether acupuncture at this acupoint in elderly patients with mild cognitive impairment can also activate neurons in these regions. Resting state and task-related functional magnetic resonance imaging showed that the pinprick senstation of acupuncture at the Taixi acupoint differed significantly between elderly patients with mild cognitive impairment and healthy elderly controls. Results showed that 20 brain regions were activated in both groups of participants, including the bilateral anterior cingulate gyrus (Brodmann areas [BA] 32, 24), left medial frontal cortex (BA 9, 10, 11), left cuneus (BA 19), left middle frontal gyrus (BA 11), left lingual gyrus (BA 18), right medial frontal gyrus (BA 11), bilateral inferior frontal gyrus (BA 47), left superior frontal gyrus (BA11), right cuneus (BA 19, 18), right superior temporal gyrus (BA 38), left subcallosal gyrus (BA 47), bilateral precuneus (BA 19), right medial frontal gyrus (BA 10), right superior frontal (BA 11), left cingulate gyrus (BA 32), left precentral gyrus (BA 6), and right fusiform gyrus (BA 19). These results suggest that acupuncture at the Taixi acupoint in elderly patients with mild cognitive impairment can also activate some brain regions.

Original languageEnglish
Pages (from-to)1163-1168
Number of pages6
JournalNeural Regeneration Research
Volume9
Issue number11
DOIs
Publication statusPublished - 2014

Scopus Subject Areas

  • Developmental Neuroscience

User-Defined Keywords

  • Acupoint
  • Acupoint specificity
  • Acupuncture
  • Brain function
  • Cognitive function
  • Functional MRI
  • Mild cognitive impairment
  • Nerve regeneration
  • Neural regeneration
  • NSFC
  • Resting state
  • Taixi (KI3)

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