Acetylcholinesterase inhibitors from Corydalis yanhusuo

Haitao XIAO, Jiao Peng, Yan Liang, Jie Yang, Xue Bai, Xiao Yan Hao*, Fu Mei Yang, Qian Yun Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from Chinese natural resources, eight isoquinoline alkaloids, tetrahydropalmatine (1), corydaline (2), protopine (3), berberine (4), palmatine (5), jatrorrhizine (6), coptisine (7) and dehydrocorydaline (8), were isolated from the methanolic extract of the tubers of Corydalis yanhusuo. Structures of these compounds were identified by spectroscopic techniques. Compounds 4-8 inhibited AChE activity in a dose-dependent manner, and the IC 50 values were 0.47±0.01, 0.74±0.06, 2.08±0.09, 1.01±0.03 and 0.62±0.05μ M, respectively. Structure-activity relationship analysis suggested that aromatisation at ring C, as well as substitutions at C-2, C-3, C-9, C-10 and C-13 affect the AChE activity of protoberberine alkaloids.

Original languageEnglish
Pages (from-to)1418-1422
Number of pages5
JournalNatural Product Research
Volume25
Issue number15
DOIs
Publication statusPublished - Sep 2011

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

User-Defined Keywords

  • Corydalis yanhusuo; acetylcholinesterase
  • isoquinoline alkaloids

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