TY - JOUR
T1 - Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications
AU - Wu, Pengfei
AU - Lin, Siyi
AU - Cao, Guodong
AU - Wu, Jiabin
AU - Jin, Hangbiao
AU - Wang, Chen
AU - Wong, Ming Hung
AU - Yang, Zhu
AU - Cai, Zongwei
N1 - Funding Information (Section snippets):
This work is supported financially by the National Natural Science Foundation of China (NSFC: 22106130), the internal grant (RC-SGT2/18-19/SCI/008) from Hong Kong Baptist University and General Research Fund (12303321) from University Grants Committee of Hong Kong SAR.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/9/5
Y1 - 2022/9/5
N2 - Microplastics (MPs; <5 mm) in the biosphere draws public concern about their potential health impacts. Humans are potentially exposed to MPs via ingestion, inhalation, and dermal contact. Ingestion and inhalation are the two major exposure pathways. An adult may consume approximately 5.1 × 103 items from table salts and up to 4.1 × 104 items via drinking water annually. Meanwhile, MP inhalation intake ranges from 0.9 × 104 to 7.9 × 104 items per year. The intake of MPs would be further distributed in different tissues and organs of humans depending on their sizes. The excretion has been discussed with the possible clearance ways (e.g., urine and feces). The review summarized the absorption, distribution, metabolic toxicity and excretion of MPs together with the attached chemicals. Moreover, the potential implications on humans are also discussed from in vitro and in vivo studies, and connecting the relationship between the physicochemical properties and the potential risks. This review will contribute to a better understanding of MPs as culprits and/or vectors linking to potential human health hazards, which will help outline the promising areas for further revealing the possible toxicity pathways.
AB - Microplastics (MPs; <5 mm) in the biosphere draws public concern about their potential health impacts. Humans are potentially exposed to MPs via ingestion, inhalation, and dermal contact. Ingestion and inhalation are the two major exposure pathways. An adult may consume approximately 5.1 × 103 items from table salts and up to 4.1 × 104 items via drinking water annually. Meanwhile, MP inhalation intake ranges from 0.9 × 104 to 7.9 × 104 items per year. The intake of MPs would be further distributed in different tissues and organs of humans depending on their sizes. The excretion has been discussed with the possible clearance ways (e.g., urine and feces). The review summarized the absorption, distribution, metabolic toxicity and excretion of MPs together with the attached chemicals. Moreover, the potential implications on humans are also discussed from in vitro and in vivo studies, and connecting the relationship between the physicochemical properties and the potential risks. This review will contribute to a better understanding of MPs as culprits and/or vectors linking to potential human health hazards, which will help outline the promising areas for further revealing the possible toxicity pathways.
KW - Exposure Pathways
KW - Microplastics
KW - Nanoplastics
KW - Plasticizer
KW - Toxicity Assessments
UR - http://www.scopus.com/inward/record.url?scp=85132728020&partnerID=8YFLogxK
U2 - 10.1016/j.jhazmat.2022.129361
DO - 10.1016/j.jhazmat.2022.129361
M3 - Review article
C2 - 35749897
AN - SCOPUS:85132728020
SN - 0304-3894
VL - 437
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
M1 - 129361
ER -
