A trinuclear heterobimetallic Ru(II)/Pt(II) complex as a chemodosimeter selective for sulfhydryl-containing amino acids and peptides

Cheuk Fai Chow; Brenda K.W. Chiu; Michael H.W. Lam; Wai Yeung Wong

doi:10.1021/ja034891x

A trinuclear heterobimetallic Ru(II)/Pt(II) complex as a chemodosimeter selective for sulfhydryl-containing amino acids and peptides

Cheuk Fai Chow, Brenda K.W. Chiu, Michael H.W. Lam^*, Wai Yeung Wong

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

125 Citations (Scopus)

Abstract

A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)₂[CN-Pt(DMSO)Cl₂]₂} (phen = 1,10-phenanthroline), is able to function as a "switch-on" luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.

Original language	English
Pages (from-to)	7802-7803
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	26
DOIs	https://doi.org/10.1021/ja034891x
Publication status	Published - 2 Jul 2003

Scopus Subject Areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "A trinuclear heterobimetallic Ru(II)/Pt(II) complex as a chemodosimeter selective for sulfhydryl-containing amino acids and peptides",

abstract = "A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)2[CN-Pt(DMSO)Cl2]2} (phen = 1,10-phenanthroline), is able to function as a {"}switch-on{"} luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.",

author = "Chow, {Cheuk Fai} and Chiu, {Brenda K.W.} and Lam, {Michael H.W.} and Wong, {Wai Yeung}",

note = "The work described in this paper was funded by a grant from the Research Grants Council of Hong Kong SAR, China (RGC Ref. No. 9040740), and a grant from CityU (Project No. 7001281). ",

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AU - Chow, Cheuk Fai

AU - Chiu, Brenda K.W.

AU - Lam, Michael H.W.

AU - Wong, Wai Yeung

N1 - The work described in this paper was funded by a grant from the Research Grants Council of Hong Kong SAR, China (RGC Ref. No. 9040740), and a grant from CityU (Project No. 7001281).

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N2 - A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)2[CN-Pt(DMSO)Cl2]2} (phen = 1,10-phenanthroline), is able to function as a "switch-on" luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.

AB - A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)2[CN-Pt(DMSO)Cl2]2} (phen = 1,10-phenanthroline), is able to function as a "switch-on" luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.

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A trinuclear heterobimetallic Ru(II)/Pt(II) complex as a chemodosimeter selective for sulfhydryl-containing amino acids and peptides

Abstract

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