A systematic review of the medicinal potential of mulberry in treating diabetes mellitus

Helin Wei, Siyuan Liu, Yijun Liao, Chuanhui Ma, Dongying Wang, Jiayun Tong, Jiafu Feng, Tao Yi*, Lin Zhu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)
165 Downloads (Pure)


Diabetes mellitus (DM) is a serious metabolic disorder which has reached epidemic proportions all over the world. Despite tremendous developments in medicinal chemistry, traditional medicine is still commonly used for the prevention and treatment of DM. Traditional herbal medicines have played a major role in the management of DM in Asian countries. In particular, mulberry has commonly been utilized in China for the treatment of DM for thousands of years. In the last decade, numerous preclinical findings have suggested that mulberry is a promising therapeutic agent for the treatment of DM, and the polyhydroxylated alkaloids, flavonoids and polysaccharides from mulberry may be the potential active components. The present review systematically summarizes the chemical composition of mulberry and the pharmacological effects of different medicinal parts on DM; these effects include influences on glucose absorption, insulin (INS) production/secretion, anti-oxidation and anti-inflammation processes. After summarizing our research findings, we will discuss the challenges and opportunities and explore the direction of future research and the potential for developing mulberry into pharmaceuticals for the widespread treatment of DM.

Original languageEnglish
Pages (from-to)1743-1770
Number of pages28
JournalThe American Journal of Chinese Medicine
Issue number8
Publication statusPublished - 2018

Scopus Subject Areas

  • Complementary and alternative medicine

User-Defined Keywords

  • Diabetes Mellitus
  • Medicinal Potential
  • Morus
  • Mulberry
  • Polyhydroxylated Alkaloids
  • Review


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