A stochastic model of fragment formation when DNA replicates

Richard Cowan, S. N. Chiu

Research output: Contribution to journalJournal articlepeer-review


The double-stranded molecule, DNA, has the unique property of replication and, because of this, it is the central molecule of life. The mechanism of replication for each single strand is intricate, involving enzymes which move along each of the single strands building a complementary copy. At the frontier of this action, the events have a strong stochastic character due to the random location on the DNA of key ‘sites' where copying commences. A model of this process is analysed. The central problem of interest is the mean length of certain ‘islands' of newly replicated DNA developed at the randomly located ‘sites'. These islands, which have been observed experimentally, are called Okazaki fragments.
Original languageEnglish
Pages (from-to)301-308
Number of pages8
JournalJournal of Applied Probability
Issue number2
Publication statusPublished - Jun 1994

User-Defined Keywords

  • Dna Replication
  • Renewal Equation
  • Okazaki Fragment


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