A standard calculation methodology for human doubly labeled water studies

John R Speakman; Yosuke Yamada; Hiroyuki Sagayama; Elena S.F. Berman; Philip N Ainslie; Lene F. Andersen; Liam J Anderson; Lenore Arab; Issaad Baddou; Kweku Bedu-Addo; Ellen E Blaak; Stephane Blanc; Alberto G Bonomi; Carlijn V.C. Bouten; Pascal Bovet; Maciej S Buchowski; Nancy F Butte; Stefan G J A Camps; Graeme Close; Jamie A Cooper; Seth A. Creasy; Sai Krupa Das; Richard Cooper; Lara R Dugas; Cara B. Ebbeling; Ulf Ekelund; Sonja Entringer; Terrence Forrester; Barry W Fudge; Annelies H Goris; Michael Gurven; Catherine Hambly; Asmaa E. El Hamdouchi; Marije B Hoos; Sumei Hu; Noorjehan Joonas; Annemiek M Joosen; Peter T. Katzmarzyk; Kitty P Kempen; Misaka Kimura; William E Kraus; Robert F Kushner; Estelle Victoria Lambert; William R Leonard; Nader Lessan; David S. Ludwig; Corby K Martin; Anine C Medin; Erwin P Meijer; James C Morehen; Marian L Neuhouser; Theresa A Nicklas; Robert M Ojiambo; Kirsi H Pietiläinen; Yannis Pitsiladis; Jacob Plange-Rhule; Guy Plasqui; Ross L Prentice; Roberto A Rabinovich; Susan B Racette; David A Raichlen; Eric Ravussin; Rebecca M Reynolds; Susan B Roberts; Albertine J Schuit; Anders M Sjödin; Eric Stice; Samuel S Urlacher; Giulio Valenti; Ludo M Van Etten; Edgar A Van Mil; Jonathan C K Wells; George Wilson; Brian M Wood; Jack A. Yanovski; Tsukasa Yoshida; Xueying Zhang; Alexia J Murphy-Alford; Cornelia U Loechl; Edward L. Melanson; Amy H Luke; Herman Pontzer; Jennifer Rood; Dale A Schoeller; Klaas R Westerterp; William W. Wong; The IAEA DLW Database Group

doi:10.1016/j.xcrm.2021.100203

A standard calculation methodology for human doubly labeled water studies

John R Speakman^*, Yosuke Yamada^*, Hiroyuki Sagayama^*, Elena S.F. Berman, Philip N Ainslie, Lene F. Andersen, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Graeme Close, Jamie A CooperSeth A. Creasy, Sai Krupa Das, Richard Cooper, Lara R Dugas, Cara B. Ebbeling, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa E. El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter T. Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle Victoria Lambert, William R Leonard, Nader Lessan, David S. Ludwig, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack A. Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia U Loechl, Edward L. Melanson, Amy H Luke^*, Herman Pontzer^*, Jennifer Rood^*, Dale A Schoeller^*, Klaas R Westerterp^*, William W. Wong^*, The IAEA DLW Database Group

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

105 Citations (Scopus)

Abstract

The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

Original language	English
Article number	100203
Number of pages	14
Journal	Cell Reports Medicine
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.xcrm.2021.100203
Publication status	Published - 16 Feb 2021

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10.1016/j.xcrm.2021.100203

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Speakman, J. R., Yamada, Y., Sagayama, H., Berman, E. S. F., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Close, G., ... The IAEA DLW Database Group (2021). A standard calculation methodology for human doubly labeled water studies. Cell Reports Medicine, 2(2), Article 100203. https://doi.org/10.1016/j.xcrm.2021.100203

@article{edac2274219849e0a09f21d95eeb54d8,

title = "A standard calculation methodology for human doubly labeled water studies",

abstract = "The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.",

author = "Speakman, {John R} and Yosuke Yamada and Hiroyuki Sagayama and Berman, {Elena S.F.} and Ainslie, {Philip N} and Andersen, {Lene F.} and Anderson, {Liam J} and Lenore Arab and Issaad Baddou and Kweku Bedu-Addo and Blaak, {Ellen E} and Stephane Blanc and Bonomi, {Alberto G} and Bouten, {Carlijn V.C.} and Pascal Bovet and Buchowski, {Maciej S} and Butte, {Nancy F} and Camps, {Stefan G J A} and Graeme Close and Cooper, {Jamie A} and Creasy, {Seth A.} and Das, {Sai Krupa} and Richard Cooper and Dugas, {Lara R} and Ebbeling, {Cara B.} and Ulf Ekelund and Sonja Entringer and Terrence Forrester and Fudge, {Barry W} and Goris, {Annelies H} and Michael Gurven and Catherine Hambly and {El Hamdouchi}, {Asmaa E.} and Hoos, {Marije B} and Sumei Hu and Noorjehan Joonas and Joosen, {Annemiek M} and Katzmarzyk, {Peter T.} and Kempen, {Kitty P} and Misaka Kimura and Kraus, {William E} and Kushner, {Robert F} and Lambert, {Estelle Victoria} and Leonard, {William R} and Nader Lessan and Ludwig, {David S.} and Martin, {Corby K} and Medin, {Anine C} and Meijer, {Erwin P} and Morehen, {James C} and Neuhouser, {Marian L} and Nicklas, {Theresa A} and Ojiambo, {Robert M} and Pietil{\"a}inen, {Kirsi H} and Yannis Pitsiladis and Jacob Plange-Rhule and Guy Plasqui and Prentice, {Ross L} and Rabinovich, {Roberto A} and Racette, {Susan B} and Raichlen, {David A} and Eric Ravussin and Reynolds, {Rebecca M} and Roberts, {Susan B} and Schuit, {Albertine J} and Sj{\"o}din, {Anders M} and Eric Stice and Urlacher, {Samuel S} and Giulio Valenti and Van Etten, {Ludo M} and Van Mil, {Edgar A} and Wells, {Jonathan C K} and George Wilson and Wood, {Brian M} and Yanovski, {Jack A.} and Tsukasa Yoshida and Xueying Zhang and Murphy-Alford, {Alexia J} and Loechl, {Cornelia U} and Melanson, {Edward L.} and Luke, {Amy H} and Herman Pontzer and Jennifer Rood and Schoeller, {Dale A} and Westerterp, {Klaas R} and Wong, {William W.} and {The IAEA DLW Database Group}",

note = "The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to Herman Pontzer. The funders played no role in the content of this manuscript.",

year = "2021",

month = feb,

day = "16",

doi = "10.1016/j.xcrm.2021.100203",

language = "English",

volume = "2",

journal = "Cell Reports Medicine",

issn = "2666-3791",

publisher = "Cell Press",

number = "2",

}

Speakman, JR, Yamada, Y, Sagayama, H, Berman, ESF, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SGJA, Close, G, Cooper, JA, Creasy, SA, Das, SK, Cooper, R, Dugas, LR, Ebbeling, CB, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, AE, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, PT, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Ludwig, DS, Martin, CK, Medin, AC, Meijer, EP, Morehen, JC, Neuhouser, ML, Nicklas, TA, Ojiambo, RM, Pietiläinen, KH, Pitsiladis, Y, Plange-Rhule, J, Plasqui, G, Prentice, RL, Rabinovich, RA, Racette, SB, Raichlen, DA, Ravussin, E, Reynolds, RM, Roberts, SB, Schuit, AJ, Sjödin, AM, Stice, E, Urlacher, SS, Valenti, G, Van Etten, LM, Van Mil, EA, Wells, JCK, Wilson, G, Wood, BM, Yanovski, JA, Yoshida, T, Zhang, X, Murphy-Alford, AJ, Loechl, CU, Melanson, EL, Luke, AH, Pontzer, H, Rood, J, Schoeller, DA, Westerterp, KR, Wong, WW & The IAEA DLW Database Group 2021, 'A standard calculation methodology for human doubly labeled water studies', Cell Reports Medicine, vol. 2, no. 2, 100203. https://doi.org/10.1016/j.xcrm.2021.100203

TY - JOUR

T1 - A standard calculation methodology for human doubly labeled water studies

AU - Speakman, John R

AU - Yamada, Yosuke

AU - Sagayama, Hiroyuki

AU - Berman, Elena S.F.

AU - Ainslie, Philip N

AU - Andersen, Lene F.

AU - Anderson, Liam J

AU - Arab, Lenore

AU - Baddou, Issaad

AU - Bedu-Addo, Kweku

AU - Blaak, Ellen E

AU - Blanc, Stephane

AU - Bonomi, Alberto G

AU - Bouten, Carlijn V.C.

AU - Bovet, Pascal

AU - Buchowski, Maciej S

AU - Butte, Nancy F

AU - Camps, Stefan G J A

AU - Close, Graeme

AU - Cooper, Jamie A

AU - Creasy, Seth A.

AU - Das, Sai Krupa

AU - Cooper, Richard

AU - Dugas, Lara R

AU - Ebbeling, Cara B.

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W

AU - Goris, Annelies H

AU - Gurven, Michael

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa E.

AU - Hoos, Marije B

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M

AU - Katzmarzyk, Peter T.

AU - Kempen, Kitty P

AU - Kimura, Misaka

AU - Kraus, William E

AU - Kushner, Robert F

AU - Lambert, Estelle Victoria

AU - Leonard, William R

AU - Lessan, Nader

AU - Ludwig, David S.

AU - Martin, Corby K

AU - Medin, Anine C

AU - Meijer, Erwin P

AU - Morehen, James C

AU - Neuhouser, Marian L

AU - Nicklas, Theresa A

AU - Ojiambo, Robert M

AU - Pietiläinen, Kirsi H

AU - Pitsiladis, Yannis

AU - Plange-Rhule, Jacob

AU - Plasqui, Guy

AU - Prentice, Ross L

AU - Rabinovich, Roberto A

AU - Racette, Susan B

AU - Raichlen, David A

AU - Ravussin, Eric

AU - Reynolds, Rebecca M

AU - Roberts, Susan B

AU - Schuit, Albertine J

AU - Sjödin, Anders M

AU - Stice, Eric

AU - Urlacher, Samuel S

AU - Valenti, Giulio

AU - Van Etten, Ludo M

AU - Van Mil, Edgar A

AU - Wells, Jonathan C K

AU - Wilson, George

AU - Wood, Brian M

AU - Yanovski, Jack A.

AU - Yoshida, Tsukasa

AU - Zhang, Xueying

AU - Murphy-Alford, Alexia J

AU - Loechl, Cornelia U

AU - Melanson, Edward L.

AU - Luke, Amy H

AU - Pontzer, Herman

AU - Rood, Jennifer

AU - Schoeller, Dale A

AU - Westerterp, Klaas R

AU - Wong, William W.

AU - The IAEA DLW Database Group

N1 - The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to Herman Pontzer. The funders played no role in the content of this manuscript.

PY - 2021/2/16

Y1 - 2021/2/16

N2 - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

AB - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85100971338&origin=inward

U2 - 10.1016/j.xcrm.2021.100203

DO - 10.1016/j.xcrm.2021.100203

M3 - Journal article

C2 - 33665639

SN - 2666-3791

VL - 2

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 2

M1 - 100203

ER -

A standard calculation methodology for human doubly labeled water studies

Abstract

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