TY - JOUR
T1 - A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage
AU - Huang, Xingcan
AU - Zhang, Qiang
AU - Yang, Yawen
AU - Chow, Lung
AU - Ma, Jie
AU - Xu, Guoqiang
AU - Guo, Fang
AU - He, Xinxin
AU - Li, Zhiyuan
AU - Zhao, Guangyao
AU - Su, Jingyou
AU - Guo, Guihuan
AU - Wang, Jiachen
AU - Jiao, Yanli
AU - Gao, Zhan
AU - Li, Jiyu
AU - Zhou, Jingkun
AU - Yiu, Chun Ki
AU - Li, Jian
AU - Chen, Yi
AU - Wu, Pengcheng
AU - Yao, Kuanming
AU - Liu, Yiming
AU - Li, Dengfeng
AU - Zhang, Binbin
AU - Chu, Hongwei
AU - Hu, Yue
AU - Huang, Ya
AU - Chen, Zhenlin
AU - Ren, Kangning
AU - Fang, Bo
AU - Yang, Rungong
AU - Li, Heng
AU - Tao, Xiaoming
AU - Ma, Xiaohui
AU - Yu, Xinge
N1 - Publisher Copyright:
© The Author(s) 2025.
Funding Information:
This work was supported by the National Key Research and Development Program of China (grant no. 2022YFB3205600), National Natural Science Foundation of China (grant no. 62122002), City University of Hong Kong (grant nos. 9667221, 9678274 and 9610444), as part of the InnoHK Project 2.2–AI-based 3D ultrasound imaging algorithm at Hong Kong Center for Cerebro-cardiovascular Health Engineering (COCHE), the Research Grants Council of the Hong Kong Special Administrative Region (grants nos. RFS2324-1S03, 11213721, 11215722, 11211523), Shenzhen Science and Technology Innovation Commission (grant no. SGDX20220530111401011), Innovation and Technology Commission of Hong Kong SAR Government (grant no. MRP020/21), Beijing Natural Science Foundation (grant no. 7232146).
PY - 2025/7/1
Y1 - 2025/7/1
N2 - Chronic wound healing is a complex and long-standing problem, that has
been a major and critical clinical concern around the world for years.
Recent advances in digital wound dressings open new possibilities for
solving the problem. Here, we report a battery-free, fully permeable,
skin-adhesive, stretchable electronic wound bandage (iSAFE) for
intelligent wound management. This electronic bandage exhibits superior
properties in multiple features and can be conformally adhered to the
skin wound. In addition, the iSAFE can accurately assess the wound
conditions in-situ and thus adaptively perform localized drug release.
The results from both in vitro and in vivo studies on animals prove the
validity of wound monitoring, wound healing boosting and intelligent
closed-loop wound management. Clinical trials on patients across age 18
to 95 with various types of wounds are performed. These results all
indicate the unique and universality of the reported technology for
wound monitoring and management.
AB - Chronic wound healing is a complex and long-standing problem, that has
been a major and critical clinical concern around the world for years.
Recent advances in digital wound dressings open new possibilities for
solving the problem. Here, we report a battery-free, fully permeable,
skin-adhesive, stretchable electronic wound bandage (iSAFE) for
intelligent wound management. This electronic bandage exhibits superior
properties in multiple features and can be conformally adhered to the
skin wound. In addition, the iSAFE can accurately assess the wound
conditions in-situ and thus adaptively perform localized drug release.
The results from both in vitro and in vivo studies on animals prove the
validity of wound monitoring, wound healing boosting and intelligent
closed-loop wound management. Clinical trials on patients across age 18
to 95 with various types of wounds are performed. These results all
indicate the unique and universality of the reported technology for
wound monitoring and management.
UR - http://www.scopus.com/inward/record.url?scp=105009550772&partnerID=8YFLogxK
U2 - 10.1038/s41467-025-61261-8
DO - 10.1038/s41467-025-61261-8
M3 - Journal article
AN - SCOPUS:105009550772
SN - 2041-1723
VL - 16
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5782
ER -