A Simple Strategy to Fabricate Phthalocyanine-Encapsulated Nanodots for Magnetic Resonance Imaging and Antitumor Phototherapy

Fengshou Wu*, Jingwen Chen, Liangliang Yue, Liangliang Yue, Haolan Li, Han Wang, Xunjin ZHU

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Photothermal agents can transfer the absorbed light to heat energy, offering a noninvasive and controllable method to kill tumor cells and tissues. Here, we develop a simple and high-output strategy to prepare photothermal nanodots (MnPc-NDs) by the self-assembly and carbonization of manganese phthalocyanine. The aggregation of phthalocyanine molecules in the nanodots induces an efficient photothermal conversion. Thanks to the high thermal stability of phthalocyanine, the macrocycle is well preserved in the core of nanodots under the controlled hydrothermal temperature. Moreover, the as-prepared MnPc-NDs disperse well in aqueous solution with an average nanoscale size around 60 nm. The intense absorption in near-infrared (NIR) region, along with efficient reactive oxygen generation, high photothermal conversion efficiency (η = 59.8%), and excellent magnetic resonance contrast performances of MnPc-NDs endow them with great potential for MRI-guided cancer phototherapy. Therefore, the contribution provides a facile way to develop theranostic MnPc-NDs for precise and efficient cancer imaging and therapy.

Original languageEnglish
Pages (from-to)3681-3689
Number of pages9
JournalACS Applied Bio Materials
Volume3
Issue number6
DOIs
Publication statusPublished - 15 Jun 2020

Scopus Subject Areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

User-Defined Keywords

  • MRI
  • nanodots
  • organic nanomaterials
  • phototherapy
  • phthalocyanine

Fingerprint

Dive into the research topics of 'A Simple Strategy to Fabricate Phthalocyanine-Encapsulated Nanodots for Magnetic Resonance Imaging and Antitumor Phototherapy'. Together they form a unique fingerprint.

Cite this