A simple Schiff base as dual-responsive fluorescent sensor for bioimaging recognition of Zn2+ and Al3+ in living cells

Haiyang Liu, Tianqi Liu, Jia Li, Youming Zhang, Jiahua Li, Jun Song*, Junle Qu, Wai Yeung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

A simple Schiff base fluorescent sensor (BDNOL) was synthesized from the reaction of picolinohydrazide and 4-(diethylamino)salicylaldehyde, and developed for selective detection of Al3+ and Zn2+. This non-fluorescent sensor displayed obvious fluorescence enhancement after binding to Al3+/Zn2+ ions with high sensitivity and selectivity, accompanied by obvious fluorescence emission enhancement (504 nm for Al3+ and 575 nm for Zn2+). The detection limits were found to be 8.30 × 10-8 M for Al3+ and 1.24 × 10-7 M for Zn2+. The binding mechanisms between BDNOL and Al3+/Zn2+ ions were supported by 1H NMR and HR-MS analysis, and a density functional theory (DFT) study. The sensing behavior was also studied with molecular logic functions of OR, AND, and NOT gates. Furthermore, the fluorescent sensor was successfully used to recognize Al3+ and Zn2+ in living cells, suggesting that this simple biosensor has great potential in biological imaging applications.

Original languageEnglish
Pages (from-to)5435-5442
Number of pages8
JournalJournal of Materials Chemistry B
Volume6
Issue number34
DOIs
Publication statusPublished - 2018

Scopus Subject Areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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