A sensitive AgNPs/CuO nanofibers non-enzymatic glucose sensor based on electrospinning technology

Baozhan Zheng, Guangyue Liu, Aiwen Yao, Yanling Xiao, Juan Du, Yong Guo, Dan Xiao*, Qin Hu, Martin M F CHOI

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

150 Citations (Scopus)


A novel sensitive non-enzymatic glucose sensor was fabricated with silver nanoparticles modified cupric oxide nanofibers (Ag/CuO NFs). The Ag/CuO NFs-indium tin oxide (ITO) electrode was prepared by firstly electrospinning AgNO3, Cu(NO3)2 and polyvinylpyrrolidone onto the surface of an ITO glass and followed with oxidization to Ag/CuO NFs by annealing in air. The Ag/CuO NFs-ITO electrode was applied to detect glucose by cyclic voltammetry (CV) and chronoamperometry. The effects of electrospinning time, AgNO3:Cu(NO3)2 mass ratio, calcination temperature and NaOH concentration on the sensitivity of glucose sensor were investigated in detail. Under the optimal conditions, CV and chronoamperometric studies revealed that, compared with CuO NFs-ITO electrode, the AgNPs modification showed a remarkable increase in the efficiency of the electro-catalytic oxidation of glucose, exhibiting a high sensitivity of 1347 μA mM-1 cm-2 and a low detection limit of 51.7 nM (S/N = 3). More importantly, the poisoning by chloride ion and the interferences from l-ascorbic acid, uric acid, lactose, sucrose, fructose, and dopamine were negligible. The Ag/CuO NFs-ITO sensor could be used for detecting glucose in real samples. This Ag/CuO NFs-ITO sensor is highly promising for non-enzymatic glucose sensing attributing to its high sensitivity, fast response, excellent stability and good reproducibility.

Original languageEnglish
Pages (from-to)431-438
Number of pages8
JournalSensors and Actuators, B: Chemical
Publication statusPublished - May 2014

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

User-Defined Keywords

  • AgNPs/CuO nanofibers
  • Electrospin
  • Glucose
  • Non-enzymatic sensor


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