TY - JOUR
T1 - A sensitive AgNPs/CuO nanofibers non-enzymatic glucose sensor based on electrospinning technology
AU - Zheng, Baozhan
AU - Liu, Guangyue
AU - Yao, Aiwen
AU - Xiao, Yanling
AU - Du, Juan
AU - Guo, Yong
AU - Xiao, Dan
AU - Hu, Qin
AU - CHOI, Martin M F
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China ( 21075083 and 21377089 ), the Doctoral Program Foundation of Institutions of Higher Education of China ( 20120181120075 ) and the China Postdoctoral Science Foundation ( 2013M1962 ). We express our sincere thanks to Dr. Nan Xu of the Chengdu First People's Hospital for providing the human blood serum samples.
PY - 2014/5
Y1 - 2014/5
N2 - A novel sensitive non-enzymatic glucose sensor was fabricated with silver nanoparticles modified cupric oxide nanofibers (Ag/CuO NFs). The Ag/CuO NFs-indium tin oxide (ITO) electrode was prepared by firstly electrospinning AgNO3, Cu(NO3)2 and polyvinylpyrrolidone onto the surface of an ITO glass and followed with oxidization to Ag/CuO NFs by annealing in air. The Ag/CuO NFs-ITO electrode was applied to detect glucose by cyclic voltammetry (CV) and chronoamperometry. The effects of electrospinning time, AgNO3:Cu(NO3)2 mass ratio, calcination temperature and NaOH concentration on the sensitivity of glucose sensor were investigated in detail. Under the optimal conditions, CV and chronoamperometric studies revealed that, compared with CuO NFs-ITO electrode, the AgNPs modification showed a remarkable increase in the efficiency of the electro-catalytic oxidation of glucose, exhibiting a high sensitivity of 1347 μA mM-1 cm-2 and a low detection limit of 51.7 nM (S/N = 3). More importantly, the poisoning by chloride ion and the interferences from l-ascorbic acid, uric acid, lactose, sucrose, fructose, and dopamine were negligible. The Ag/CuO NFs-ITO sensor could be used for detecting glucose in real samples. This Ag/CuO NFs-ITO sensor is highly promising for non-enzymatic glucose sensing attributing to its high sensitivity, fast response, excellent stability and good reproducibility.
AB - A novel sensitive non-enzymatic glucose sensor was fabricated with silver nanoparticles modified cupric oxide nanofibers (Ag/CuO NFs). The Ag/CuO NFs-indium tin oxide (ITO) electrode was prepared by firstly electrospinning AgNO3, Cu(NO3)2 and polyvinylpyrrolidone onto the surface of an ITO glass and followed with oxidization to Ag/CuO NFs by annealing in air. The Ag/CuO NFs-ITO electrode was applied to detect glucose by cyclic voltammetry (CV) and chronoamperometry. The effects of electrospinning time, AgNO3:Cu(NO3)2 mass ratio, calcination temperature and NaOH concentration on the sensitivity of glucose sensor were investigated in detail. Under the optimal conditions, CV and chronoamperometric studies revealed that, compared with CuO NFs-ITO electrode, the AgNPs modification showed a remarkable increase in the efficiency of the electro-catalytic oxidation of glucose, exhibiting a high sensitivity of 1347 μA mM-1 cm-2 and a low detection limit of 51.7 nM (S/N = 3). More importantly, the poisoning by chloride ion and the interferences from l-ascorbic acid, uric acid, lactose, sucrose, fructose, and dopamine were negligible. The Ag/CuO NFs-ITO sensor could be used for detecting glucose in real samples. This Ag/CuO NFs-ITO sensor is highly promising for non-enzymatic glucose sensing attributing to its high sensitivity, fast response, excellent stability and good reproducibility.
KW - AgNPs/CuO nanofibers
KW - Electrospin
KW - Glucose
KW - Non-enzymatic sensor
UR - http://www.scopus.com/inward/record.url?scp=84894140087&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2014.01.046
DO - 10.1016/j.snb.2014.01.046
M3 - Journal article
AN - SCOPUS:84894140087
SN - 0925-4005
VL - 195
SP - 431
EP - 438
JO - Sensors and Actuators B: Chemical
JF - Sensors and Actuators B: Chemical
ER -