A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo

Li Juan Liu, Sheng Lin, Daniel Shiu Hin Chan, Chi Teng Vong, Pui Man Hoi, Chun Yuen Wong, Edmond Dik Lung MA*, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Metal-containing complexes have arisen as viable alternatives to organic molecules as therapeutic agents. Metal complexes possess a number of advantages compared to conventional carbon-based compounds, such as distinct geometries, interesting electronic properties, variable oxidation states and the ability to arrange different ligands around the metal centre in a precise fashion. Meanwhile, nitric oxide (NO) plays key roles in the regulation of angiogenesis, vascular permeability and inflammation. We herein report a novel cyclometalated rhodium(III) complex as an inhibitor of lipopolysaccharides (LPS)-induced NO production in RAW264.7 macrophages. Experiments suggested that the inhibition of NO production in cells by complex 1 was mediated through the down-regulation of nuclear factor-κB (NF-κB) activity. Furthermore, complex 1 inhibited angiogenesis in human umbilical vein endothelial cells (HUVECs) as revealed by an endothelial tube formation assay. This study demonstrates that kinetically inert rhodium(III) complexes may be potentially developed as effective anti-angiogenic agents.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume140
DOIs
Publication statusPublished - Nov 2014

Scopus Subject Areas

  • Biochemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Angiogenesis
  • Metal complex
  • NF-κB
  • Nitric oxide
  • Rhodium

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