A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease

Hai Jing Zhong*, Wanhe Wang, Tian Shu Kang, Hui Yan, Yali Yang, Lipeng Xu, Yuqiang Wang, Edmond Dik Lung MA, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

We report herein the identification of the rhodium(III) complex [Rh(phq)2(MOPIP)]+ (1) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalJournal of Medicinal Chemistry
Volume60
Issue number1
DOIs
Publication statusPublished - 12 Jan 2017

Scopus Subject Areas

  • Molecular Medicine
  • Drug Discovery

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