A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease

Hai Jing Zhong; Wanhe Wang; Tian Shu Kang; Hui Yan; Yali Yang; Lipeng Xu; Yuqiang Wang; Dik Lung Ma; Chung Hang Leung

doi:10.1021/acs.jmedchem.6b00250

A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease

Hai Jing Zhong^*, Wanhe Wang, Tian Shu Kang, Hui Yan, Yali Yang, Lipeng Xu, Yuqiang Wang, Dik Lung Ma^*, Chung Hang Leung^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

68 Citations (Scopus)

Abstract

We report herein the identification of the rhodium(III) complex [Rh(phq)₂(MOPIP)]⁺ (1) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.

Original language	English
Pages (from-to)	497-503
Number of pages	7
Journal	Journal of Medicinal Chemistry
Volume	60
Issue number	1
Early online date	23 Dec 2016
DOIs	https://doi.org/10.1021/acs.jmedchem.6b00250
Publication status	Published - 12 Jan 2017

Scopus Subject Areas

Molecular Medicine
Drug Discovery

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.jmedchem.6b00250

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Zhong, H. J., Wang, W., Kang, T. S., Yan, H., Yang, Y., Xu, L., Wang, Y., Ma, D. L., & Leung, C. H. (2017). A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease. Journal of Medicinal Chemistry, 60(1), 497-503. https://doi.org/10.1021/acs.jmedchem.6b00250

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title = "A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease",

abstract = "We report herein the identification of the rhodium(III) complex [Rh(phq)2(MOPIP)]+ (1) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.",

author = "Zhong, {Hai Jing} and Wanhe Wang and Kang, {Tian Shu} and Hui Yan and Yali Yang and Lipeng Xu and Yuqiang Wang and Ma, {Dik Lung} and Leung, {Chung Hang}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/12301115, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12 − Oligoswitch), National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2016, Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund, Macao SAR (098/2014/A2), and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM, and MRG044/LCH/2015/ICMS). Publisher copyright: {\textcopyright} 2016 American Chemical Society",

year = "2017",

month = jan,

day = "12",

doi = "10.1021/acs.jmedchem.6b00250",

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Zhong, HJ, Wang, W, Kang, TS, Yan, H, Yang, Y, Xu, L, Wang, Y, Ma, DL & Leung, CH 2017, 'A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease', Journal of Medicinal Chemistry, vol. 60, no. 1, pp. 497-503. https://doi.org/10.1021/acs.jmedchem.6b00250

A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease. / Zhong, Hai Jing; Wang, Wanhe; Kang, Tian Shu et al.
In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 12.01.2017, p. 497-503.

Research output: Contribution to journal › Journal article › peer-review

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T1 - A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease

AU - Zhong, Hai Jing

AU - Wang, Wanhe

AU - Kang, Tian Shu

AU - Yan, Hui

AU - Yang, Yali

AU - Xu, Lipeng

AU - Wang, Yuqiang

AU - Ma, Dik Lung

AU - Leung, Chung Hang

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/12301115, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12 − Oligoswitch), National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2016, Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund, Macao SAR (098/2014/A2), and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM, and MRG044/LCH/2015/ICMS). Publisher copyright: © 2016 American Chemical Society

PY - 2017/1/12

Y1 - 2017/1/12

N2 - We report herein the identification of the rhodium(III) complex [Rh(phq)2(MOPIP)]+ (1) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.

AB - We report herein the identification of the rhodium(III) complex [Rh(phq)2(MOPIP)]+ (1) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.

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U2 - 10.1021/acs.jmedchem.6b00250

DO - 10.1021/acs.jmedchem.6b00250

M3 - Journal article

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SN - 0022-2623

VL - 60

SP - 497

EP - 503

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 1

ER -

A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease

Abstract

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