TY - JOUR
T1 - A review of drug-induced liver injury databases
AU - Luo, Guangwen
AU - Shen, Yiting
AU - Yang, Lizhu
AU - LYU, Aiping
AU - Xiang, Zheng
N1 - Funding Information:
We would like to thank Dr. Hongdong Li for his useful discussions, comments and suggestions throughout this entire work. The authors acknowledge financial support from the Nature Foundation Committee of China (No. 31300819).
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this field. In this study, we provide an overview of these databases, including the liver injury-specific databases LiverTox, LTKB, Open TG-GATEs, LTMap and Hepatox, and the general databases, T3DB, DrugBank, DITOP, DART, CTD and HSDB. The features and limitations of these databases are summarized and discussed in detail. Apart from their powerful functions, we believe that these databases can be improved in several ways: by providing the data about the molecular targets involved in liver toxicity, by incorporating information regarding liver injuries caused by drug interactions, and by regularly updating the data.
AB - Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this field. In this study, we provide an overview of these databases, including the liver injury-specific databases LiverTox, LTKB, Open TG-GATEs, LTMap and Hepatox, and the general databases, T3DB, DrugBank, DITOP, DART, CTD and HSDB. The features and limitations of these databases are summarized and discussed in detail. Apart from their powerful functions, we believe that these databases can be improved in several ways: by providing the data about the molecular targets involved in liver toxicity, by incorporating information regarding liver injuries caused by drug interactions, and by regularly updating the data.
KW - Databases
KW - Drug-induced liver injury
KW - Hepatotoxicity
KW - Liver toxicity
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=85024505584&partnerID=8YFLogxK
U2 - 10.1007/s00204-017-2024-8
DO - 10.1007/s00204-017-2024-8
M3 - Review article
C2 - 28717830
AN - SCOPUS:85024505584
SN - 0340-5761
VL - 91
SP - 3039
EP - 3049
JO - Archives of Toxicology
JF - Archives of Toxicology
IS - 9
ER -