A review of drug-induced liver injury databases

Guangwen Luo, Yiting Shen, Lizhu Yang, Aiping LYU, Zheng Xiang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this field. In this study, we provide an overview of these databases, including the liver injury-specific databases LiverTox, LTKB, Open TG-GATEs, LTMap and Hepatox, and the general databases, T3DB, DrugBank, DITOP, DART, CTD and HSDB. The features and limitations of these databases are summarized and discussed in detail. Apart from their powerful functions, we believe that these databases can be improved in several ways: by providing the data about the molecular targets involved in liver toxicity, by incorporating information regarding liver injuries caused by drug interactions, and by regularly updating the data.

Original languageEnglish
Pages (from-to)3039-3049
Number of pages11
JournalArchives of Toxicology
Volume91
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017

Scopus Subject Areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Databases
  • Drug-induced liver injury
  • Hepatotoxicity
  • Liver toxicity
  • Review

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