A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Jing Xiang Zhang; Hongguang Li; Chi Fai Chan; Rongfeng Lan; Wai Lun Chan; Ga Lai Law; Rick W K WONG; Ka-Leung WONG

doi:10.1039/c2cc34963a

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Jing Xiang Zhang^*, Hongguang Li, Chi Fai Chan, Rongfeng Lan, Wai Lun Chan, Ga Lai Law, Rick W K WONG, Ka-Leung WONG

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

50 Citations (Scopus)

Abstract

An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (Φ_Δ = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.

Original language	English
Pages (from-to)	9646-9648
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	77
DOIs	https://doi.org/10.1039/c2cc34963a
Publication status	Published - 29 Aug 2012

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc34963a

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title = "A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy",

abstract = "An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (ΦΔ = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.",

author = "Zhang, {Jing Xiang} and Hongguang Li and Chan, {Chi Fai} and Rongfeng Lan and Chan, {Wai Lun} and Law, {Ga Lai} and WONG, {Rick W K} and Ka-Leung WONG",

note = "The work described in this paper was supported by grants from the HKRGC (HKBU 202210 and 202811) and HKBU (FRG2/09-10/058).",

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doi = "10.1039/c2cc34963a",

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AU - Zhang, Jing Xiang

AU - Li, Hongguang

AU - Chan, Chi Fai

AU - Lan, Rongfeng

AU - Chan, Wai Lun

AU - Law, Ga Lai

AU - WONG, Rick W K

AU - WONG, Ka-Leung

N1 - The work described in this paper was supported by grants from the HKRGC (HKBU 202210 and 202811) and HKBU (FRG2/09-10/058).

PY - 2012/8/29

Y1 - 2012/8/29

N2 - An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (ΦΔ = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.

AB - An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (ΦΔ = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.

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U2 - 10.1039/c2cc34963a

DO - 10.1039/c2cc34963a

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SN - 1359-7345

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EP - 9648

JO - Chemical Communications

JF - Chemical Communications

IS - 77

ER -

A potential water-soluble ytterbium-based porphyrin–cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

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